Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aau9952 |
NEURODEVELOPMENT Branch-restricted localization of phosphatase Prl-1 specifies axonal synaptogenesis domains | |
Urwyler, Olivier1,2; Izadifar, Azadeh1,3; Vandenbogaerde, Sofie1; Sachse, Sonja1; Misbaer, Anke1,3; Schmucker, Dietmar1,3 | |
2019-05-03 | |
发表期刊 | SCIENCE
![]() |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6439页码:454-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Belgium; Switzerland |
英文摘要 | Central nervous system (CNS) circuit development requires subcellular control of synapse formation and patterning of synapse abundance. We identified the Drosophila membrane-anchored phosphatase of regenerating liver (Prl-1) as an axon-intrinsic factor that promotes synapse formation in a spatially restricted fashion. The loss of Prl-1 in mechanosensory neurons reduced the number of CNS presynapses localized on a single axon collateral and organized as a terminal arbor. Flies lacking all Prl-1 protein had locomotor defects. The overexpression of Prl-1 induced ectopic synapses. In mechanosensory neurons, Prl-1 modulates the insulin receptor (InR) signaling pathway within a single contralateral axon compartment, thereby affecting the number of synapses. The axon branch-specific localization and function of Prl-1 depend on untranslated regions of the prl-1 messenger RNA (mRNA). Therefore, compartmentalized restriction of Prl-1 serves as a specificity factor for the subcellular control of axonal synaptogenesis. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000466809600026 |
WOS关键词 | MOLECULAR-MECHANISMS ; MONOCLONAL-ANTIBODIES ; CELL-GROWTH ; IN-VIVO ; DROSOPHILA ; RECEPTOR ; EXPRESSION ; METASTASIS ; PROTEIN ; KINASE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201353 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.IVIB Ctr Brain & Dis Res, Leuven, Belgium; 2.Univ Zurich, Inst Mol Life Sci, CH-8057 Zurich, Switzerland; 3.Katholieke Univ Leuven, Dept Neurosci, Leuven, Belgium |
推荐引用方式 GB/T 7714 | Urwyler, Olivier,Izadifar, Azadeh,Vandenbogaerde, Sofie,et al. NEURODEVELOPMENT Branch-restricted localization of phosphatase Prl-1 specifies axonal synaptogenesis domains[J]. SCIENCE,2019,364(6439):454-+. |
APA | Urwyler, Olivier,Izadifar, Azadeh,Vandenbogaerde, Sofie,Sachse, Sonja,Misbaer, Anke,&Schmucker, Dietmar.(2019).NEURODEVELOPMENT Branch-restricted localization of phosphatase Prl-1 specifies axonal synaptogenesis domains.SCIENCE,364(6439),454-+. |
MLA | Urwyler, Olivier,et al."NEURODEVELOPMENT Branch-restricted localization of phosphatase Prl-1 specifies axonal synaptogenesis domains".SCIENCE 364.6439(2019):454-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论