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DOI | 10.1126/science.aaw5188 |
Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes | |
Maeda, Shoji1; Qu, Qianhui1,2; Robertson, Michael J.1,2; Skiniotis, Georgios1,2; Kobilka, Brian K.1 | |
2019-05-10 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6440页码:552-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Muscarinic acetylcholine receptors are G protein-coupled receptors that respond to acetylcholine and play important signaling roles in the nervous system. There are five muscarinic receptor subtypes (M1R to M5R), which, despite sharing a high degree of sequence identity in the transmembrane region, couple to different heterotrimeric GTP-binding proteins (G proteins) to transmit signals. M1R, M3R, and M5R couple to the G(q/11) family, whereas M2R and M4R couple to the G(i/o) family. Here, we present and compare the cryo-electron microscopy structures of M1R in complex with G(11) and M2R in complex with G(oA). The M1R-G(11) complex exhibits distinct features, including an extended transmembrane helix 5 and carboxyl-terminal receptor tail that interacts with G protein. Detailed analysis of these structures provides a framework for understanding the molecular determinants of G-protein coupling selectivity. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000467631800036 |
WOS关键词 | CRYO-EM STRUCTURE ; AMINO-ACID ; ALLOSTERIC MODULATION ; CRYSTAL-STRUCTURE ; ACTIVATION ; SPECIFICITY ; SELECTIVITY ; REGION ; IDENTIFICATION ; VISUALIZATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201393 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, Sch Med, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA; 2.Stanford Univ, Sch Med, Dept Struct Biol, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Maeda, Shoji,Qu, Qianhui,Robertson, Michael J.,et al. Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes[J]. SCIENCE,2019,364(6440):552-+. |
APA | Maeda, Shoji,Qu, Qianhui,Robertson, Michael J.,Skiniotis, Georgios,&Kobilka, Brian K..(2019).Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.SCIENCE,364(6440),552-+. |
MLA | Maeda, Shoji,et al."Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes".SCIENCE 364.6440(2019):552-+. |
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