GSTDTAP  > 地球科学
DOI10.1126/science.aaw5188
Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes
Maeda, Shoji1; Qu, Qianhui1,2; Robertson, Michael J.1,2; Skiniotis, Georgios1,2; Kobilka, Brian K.1
2019-05-10
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2019
卷号364期号:6440页码:552-+
文章类型Article
语种英语
国家USA
英文摘要

Muscarinic acetylcholine receptors are G protein-coupled receptors that respond to acetylcholine and play important signaling roles in the nervous system. There are five muscarinic receptor subtypes (M1R to M5R), which, despite sharing a high degree of sequence identity in the transmembrane region, couple to different heterotrimeric GTP-binding proteins (G proteins) to transmit signals. M1R, M3R, and M5R couple to the G(q/11) family, whereas M2R and M4R couple to the G(i/o) family. Here, we present and compare the cryo-electron microscopy structures of M1R in complex with G(11) and M2R in complex with G(oA). The M1R-G(11) complex exhibits distinct features, including an extended transmembrane helix 5 and carboxyl-terminal receptor tail that interacts with G protein. Detailed analysis of these structures provides a framework for understanding the molecular determinants of G-protein coupling selectivity.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000467631800036
WOS关键词CRYO-EM STRUCTURE ; AMINO-ACID ; ALLOSTERIC MODULATION ; CRYSTAL-STRUCTURE ; ACTIVATION ; SPECIFICITY ; SELECTIVITY ; REGION ; IDENTIFICATION ; VISUALIZATION
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/201393
专题地球科学
资源环境科学
气候变化
作者单位1.Stanford Univ, Sch Med, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA;
2.Stanford Univ, Sch Med, Dept Struct Biol, Stanford, CA 94305 USA
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GB/T 7714
Maeda, Shoji,Qu, Qianhui,Robertson, Michael J.,et al. Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes[J]. SCIENCE,2019,364(6440):552-+.
APA Maeda, Shoji,Qu, Qianhui,Robertson, Michael J.,Skiniotis, Georgios,&Kobilka, Brian K..(2019).Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.SCIENCE,364(6440),552-+.
MLA Maeda, Shoji,et al."Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes".SCIENCE 364.6440(2019):552-+.
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