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DOI | 10.1126/science.aau0812 |
LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling | |
Choi, Jin Huk1; Zhong, Xue1; McAlpine, William1; Liao, Tzu-Chieh1; Zhang, Duanwu1; Fang, Beibei1; Russell, Jamie1; Ludwig, Sara1; Nair-Gill, Evan1; Zhang, Zhao1; Wang, Kuan-wen1; Misawa, Takuma1; Zhan, Xiaoming1; Choi, Mihwa1; Wang, Tao1,2; Li, Xiaohong1; Tang, Miao1; Sun, Qihua1; Yu, Liyang1; Murray, Anne R.1; Moresco, Eva Marie Y.1; Beutler, Bruce1 | |
2019-05-10 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6440页码:545-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Precise control of Wnt signaling is necessary for immune system development. In this study, we detected severely impaired development of all lymphoid lineages in mice, resulting from an N-ethyl-N-nitrosourea-induced mutation in the limb region 1-like gene (Lmbr1l), which encodes a membrane-spanning protein with no previously described function in immunity. The interaction of LMBR1L with glycoprotein 78 (GP78) and ubiquitin-associated domain-containing protein 2 (UBAC2) attenuated Wnt signaling in lymphocytes by preventing the maturation of FZD6 and LRP6 through ubiquitination within the endoplasmic reticulum and by stabilizing "destruction complex" proteins. LMBR1L-deficient T cells exhibited hallmarks of Wnt/beta-catenin activation and underwent apoptotic cell death in response to proliferative stimuli. LMBR1L has an essential function during lymphopoiesis and lymphoid activation, acting as a negative regulator of the Wnt/beta-catenin pathway. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000467631800032 |
WOS关键词 | CELLULAR INTERNALIZATION ; WNT ; LIPOCALIN-1 ; DEGRADATION ; CLONING |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201402 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Texas Southwestern Med Ctr Dallas, Ctr Genet Host Def, Dallas, TX 75390 USA; 2.Univ Texas Southwestern Med Ctr Dallas, Dept Clin Sci, Quantitat Biomed Res Ctr, Dallas, TX 75390 USA |
推荐引用方式 GB/T 7714 | Choi, Jin Huk,Zhong, Xue,McAlpine, William,et al. LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling[J]. SCIENCE,2019,364(6440):545-+. |
APA | Choi, Jin Huk.,Zhong, Xue.,McAlpine, William.,Liao, Tzu-Chieh.,Zhang, Duanwu.,...&Beutler, Bruce.(2019).LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.SCIENCE,364(6440),545-+. |
MLA | Choi, Jin Huk,et al."LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling".SCIENCE 364.6440(2019):545-+. |
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