Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaq1165 |
URI is required to maintain intestinal architecture during ionizing radiation | |
Chaves-Perez, Almudena1,3; Yilmaz, Mahmut1; Perna, Cristian2; de la Rosa, Sergio1,3; Djouder, Nabil1,3 | |
2019-05-31 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6443页码:849-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Spain |
英文摘要 | Ionizing radiation (IR) can cause gastrointestinal syndrome (GIS), a lethal disorder, by means of unknown mechanisms. We show that high-dose irradiation increases unconventional prefoldin RPB5 interactor (URI) levels in mouse intestinal crypt, but organ regeneration correlates with URI reductions. URI overexpression in intestine protects mice from radiationinduced GIS, whereas halving URI expression sensitizes mice to IR. URI specifically inhibits beta-catenin in stem cell-like label-retaining (LR) cells, which are essential for organ regeneration after IR. URI reduction activates beta-catenin-induced c-MYC expression, causing proliferation of and DNA damage to LR cells, rendering them radiosensitive. Therefore, URI labels LR cells which promote tissue regeneration in response to high-dose irradiation, and c-MYC inhibitors could be countermeasures for humans at risk of developing GIS. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000469887900052 |
WOS关键词 | STEM-CELLS ; GASTROINTESTINAL SYNDROME ; COLORECTAL-CANCER ; MICE ; MARKER ; CRYPT ; P53 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201533 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.CNIO, Growth Factors Nutrients & Canc Grp, Canc Cell Biol Programme, Madrid 28029, Spain; 2.Hosp Univ Ramon y Cajal IRYCIS, Dept Pathol, Madrid 28034, Spain; 3.CNIO, Growth Factors Nutrients & Canc Grp, Mol Oncol Programme, Madrid 28029, Spain |
推荐引用方式 GB/T 7714 | Chaves-Perez, Almudena,Yilmaz, Mahmut,Perna, Cristian,et al. URI is required to maintain intestinal architecture during ionizing radiation[J]. SCIENCE,2019,364(6443):849-+. |
APA | Chaves-Perez, Almudena,Yilmaz, Mahmut,Perna, Cristian,de la Rosa, Sergio,&Djouder, Nabil.(2019).URI is required to maintain intestinal architecture during ionizing radiation.SCIENCE,364(6443),849-+. |
MLA | Chaves-Perez, Almudena,et al."URI is required to maintain intestinal architecture during ionizing radiation".SCIENCE 364.6443(2019):849-+. |
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