Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw7567 |
Organoids by design | |
Takebe, Takanori1,2,3,4; Wells, James M.1,3,5 | |
2019-06-07 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6444页码:956-959 |
文章类型 | Review |
语种 | 英语 |
国家 | USA; Japan |
英文摘要 | Organoids are multicellular structures that can be derived from adult organs or pluripotent stem cells. Early versions of organoids range from simple epithelial structures to complex, disorganized tissues with large cellular diversity. The current challenge is to engineer cellular complexity into organoids in a controlled manner that results in organized assembly and acquisition of tissue function. These efforts have relied on studies of organ assembly during embryonic development and have resulted in the development of organoids with multilayer tissue complexity and higher-order functions. We discuss how the next generation of organoids can be designed by means of an engineering-based narrative design to control patterning, assembly, morphogenesis, growth, and function. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000482914100048 |
WOS关键词 | IN-VIVO MODEL ; SELF-ORGANIZATION ; TISSUES ; DYNAMICS ; BIOLOGY ; FORCE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201591 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Cincinnati Childrens Hosp Med Ctr, Ctr Stem Cell & Organoid Med CuSTOM, Cincinnati, OH 45229 USA; 2.Cincinnati Childrens Hosp Med Ctr, Div Gastroenterol Hepatol & Nutr, Cincinnati, OH 45229 USA; 3.Cincinnati Childrens Hosp Med Ctr, Div Dev Biol, Cincinnati, OH 45229 USA; 4.TMDU, Inst Res, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138510, Japan; 5.Cincinnati Childrens Hosp Med Ctr, Div Endocrinol, Cincinnati, OH 45229 USA |
推荐引用方式 GB/T 7714 | Takebe, Takanori,Wells, James M.. Organoids by design[J]. SCIENCE,2019,364(6444):956-959. |
APA | Takebe, Takanori,&Wells, James M..(2019).Organoids by design.SCIENCE,364(6444),956-959. |
MLA | Takebe, Takanori,et al."Organoids by design".SCIENCE 364.6444(2019):956-959. |
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