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DOI | 10.1126/science.aas9536 |
Spatiotemporal structure of cell fate decisions in murine neural crest | |
Soldatov, Ruslan1; Kaucka, Marketa2,3; Kastriti, Maria Eleni2,3; Petersen, Julian2,3; Chontorotzea, Tatiana3; Englmaier, Lukas2; Akkuratova, Natalia3,4; Yang, Yunshi3; Haring, Martin5; Dyachuk, Viacheslav6,7; Bock, Christoph8,9,10; Farlik, Matthias8; Piacentino, Michael L.11; Boismoreau, Franck12; Hilscher, Markus M.13; Yokota, Chika13; Qian, Xiaoyan13,14; Nilsson, Mats13; Bronner, Marianne E.; Croci, Laura15,16; Hsiao, Wen-Yu; Guertin, David A.17; Brunet, Jean-Francois; Consalez, Gian Giacomo15,16; Ernfors, Patrik5; Fried, Kaj6; Kharchenko, Peter V.1,18; Adameyko, Igor2,3 | |
2019-06-07 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6444页码:971-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Austria; Sweden; Russia; Germany; France; Italy |
英文摘要 | Neural crest cells are embryonic progenitors that generate numerous cell types in vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become biased toward neuronal lineages when they delaminate from the neural tube, whereas cranial neural crest cells acquire ectomesenchyme potential dependent on activation of the transcription factor Twist1. The choices that neural crest cells make to become sensory, glial, autonomic, or mesenchymal cells can be formalized as a series of sequential binary decisions. Each branch of the decision tree involves initial coactivation of bipotential properties followed by gradual shifts toward commitment. Competing fate programs are coactivated before cells acquire fate-specific phenotypic traits. Determination of a specific fate is achieved by increased synchronization of relevant programs and concurrent repression of competing fate programs. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000471079600001 |
WOS关键词 | EMBRYONIC STEM-CELLS ; LOSS-OF-FUNCTION ; ROOF PLATE ; LINEAGE-COMMITMENT ; RNA-ANALYSIS ; EXPRESSION ; DIFFERENTIATION ; IDENTITY ; IDENTIFICATION ; NEUROBLASTOMA |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201603 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA; 2.Med Univ Vienna, Ctr Brain Res, Dept Mol Neurosci, A-1090 Vienna, Austria; 3.Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden; 4.St Petersburg Univ, Inst Translat Biomed, St Petersburg 199034, Russia; 5.Karolinska Inst, Div Mol Neurobiol, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden; 6.Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden; 7.Russian Acad Sci, Far Eastern Branch, Natl Sci Ctr Marine Biol, Vladivostok 690041, Russia; 8.Austrian Acad Sci, CeMM Res Ctr Mol Med, Vienna, Austria; 9.Med Univ Vienna, Dept Lab Med, Vienna, Austria; 10.Max Planck Inst Informat, Saarbrucken, Germany; 11.CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA; 12.PSL Res Univ, Ecole Normale Super, Inst Biol ENS IBENS, INSERM,CNRS, F-75005 Paris, France; 13.Stockholm Univ, Dept Biophys & Biochem, Sci Life Lab, S-17165 Solna, Sweden; 14.Cartana AB, S-17165 Solna, Sweden; 15.Ist Sci San Raffaele, I-20132 Milan, Italy; 16.Univ Vita Salute San Raffaele, I-20132 Milan, Italy; 17.Univ Massachusetts, Med Sch, Program Mol Med, Worcester, MA 01605 USA; 18.Harvard Stem Cell Inst, Cambridge, MA 02138 USA |
推荐引用方式 GB/T 7714 | Soldatov, Ruslan,Kaucka, Marketa,Kastriti, Maria Eleni,et al. Spatiotemporal structure of cell fate decisions in murine neural crest[J]. SCIENCE,2019,364(6444):971-+. |
APA | Soldatov, Ruslan.,Kaucka, Marketa.,Kastriti, Maria Eleni.,Petersen, Julian.,Chontorotzea, Tatiana.,...&Adameyko, Igor.(2019).Spatiotemporal structure of cell fate decisions in murine neural crest.SCIENCE,364(6444),971-+. |
MLA | Soldatov, Ruslan,et al."Spatiotemporal structure of cell fate decisions in murine neural crest".SCIENCE 364.6444(2019):971-+. |
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