Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw2872 |
Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features | |
Buisson, Remi1,2; Langenbucher, Adam1; Bowen, Danae2; Kwan, Eugene E.1; Benes, Cyril H.1; Zou, Lee1,3; Lawrence, Michael S.1,3,4 | |
2019-06-28 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6447页码:1251-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Cancer drivers require statistical modeling to distinguish them from passenger events, which accumulate during tumorigenesis but provide no fitness advantage to cancer cells. The discovery of driver genes and mutations relies on the assumption that exact positional recurrence is unlikely by chance; thus, the precise sharing of mutations across patients identifies drivers. Examining the mutation landscape in cancer genomes, we found that many recurrent cancer mutations previously designated as drivers are likely passengers. Our integrated bioinformatic and biochemical analyses revealed that these passenger hotspot mutations arise from the preference of APOBEC3A, a cytidine deaminase, for DNA stem-loops. Conversely, recurrent APOBEC-signature mutations not in stem-loops are enriched in well-characterized driver genes and may predict new drivers. This demonstrates that mesoscale genomic features need to be integrated into computational models aimed at identifying mutations linked to diseases. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000473271300037 |
WOS关键词 | STRUCTURAL BASIS ; DNA-DAMAGE ; MUTAGENESIS ; PATTERNS ; DEAMINASE ; STRAND ; EXPRESSION ; SIGNATURES ; RECURRENT ; REPAIR |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201753 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Harvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02115 USA; 2.Univ Calif Irvine, Dept Biol Chem, Ctr Epigenet & Metab, Chao Family Comprehens Canc Ctr, Irvine, CA 92717 USA; 3.Harvard Med Sch, Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02115 USA; 4.Broad Inst Harvard & MIT, Cambridge, MA USA |
推荐引用方式 GB/T 7714 | Buisson, Remi,Langenbucher, Adam,Bowen, Danae,et al. Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features[J]. SCIENCE,2019,364(6447):1251-+. |
APA | Buisson, Remi.,Langenbucher, Adam.,Bowen, Danae.,Kwan, Eugene E..,Benes, Cyril H..,...&Lawrence, Michael S..(2019).Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features.SCIENCE,364(6447),1251-+. |
MLA | Buisson, Remi,et al."Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features".SCIENCE 364.6447(2019):1251-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论