Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aax1837 |
Cryptic genetic variation accelerates evolution by opening access to diverse adaptive peaks | |
Zheng, Jia1,2; Payne, Joshua L.2,3; Wagnere, Andreas1,2,4 | |
2019-07-26 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6451页码:347-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland; USA |
英文摘要 | Cryptic genetic variation can facilitate adaptation in evolving populations. To elucidate the underlying genetic mechanisms, we used directed evolution in Escherichia coil to accumulate variation in populations of yellow fluorescent proteins and then evolved these proteins toward the new phenotype of green fluorescence. Populations with cryptic variation evolved adaptive genotypes with greater diversity and higher fitness than populations without cryptic variation, which converged on similar genotypes. Populations with cryptic variation accumulated neutral or deleterious mutations that break the constraints on the order in which adaptive mutations arise. In doing so, cryptic variation opens paths to adaptive genotypes, creates historical contingency, and reduces the predictability of evolution by allowing different replicate populations to climb different adaptive peaks and explore otherwise-inaccessible regions of an adaptive landscape. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000477703100034 |
WOS关键词 | FITNESS LANDSCAPES ; SEQUENCE SPACE ; ADAPTATION ; ROBUSTNESS ; EPISTASIS ; HSP90 ; PREDICTABILITY ; POPULATIONS ; RESISTANCE ; PHENOTYPE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201943 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Zurich, Dept Evolutionary Biol & Environm Studies, Zurich, Switzerland; 2.Swiss Inst Bioinformat, Quartier Sorge Batiment Genopode, Lausanne, Switzerland; 3.Swiss Fed Inst Technol, Inst Integrat Biol, Zurich, Switzerland; 4.Santa Fe Inst, Santa Fe, NM 87501 USA |
推荐引用方式 GB/T 7714 | Zheng, Jia,Payne, Joshua L.,Wagnere, Andreas. Cryptic genetic variation accelerates evolution by opening access to diverse adaptive peaks[J]. SCIENCE,2019,365(6451):347-+. |
APA | Zheng, Jia,Payne, Joshua L.,&Wagnere, Andreas.(2019).Cryptic genetic variation accelerates evolution by opening access to diverse adaptive peaks.SCIENCE,365(6451),347-+. |
MLA | Zheng, Jia,et al."Cryptic genetic variation accelerates evolution by opening access to diverse adaptive peaks".SCIENCE 365.6451(2019):347-+. |
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