Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw5118 |
Resetting histone modifications during human parental-to-zygotic transition | |
Xia, Weikun1; Xu, Jiawei2; Yu, Guang1; Yao, Guidong2; Xu, Kai1; Ma, Xueshan2; Zhang, Nan2; Liu, Bofeng1; Li, Tong2; Lin, Zili1; Chen, Xia3; Li, Lijia1; Wang, Qiujun1; Shi, Dayuan2; Shi, Senlin2; Zhang, Yile2; Song, Wenyan2; Jin, Haixia2; Hu, Linli2; Bu, Zhiqin2; Wang, Yang2; Na, Jie3; Xie, Wei1; Sun, Ying-Pu2 | |
2019-07-26 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6451页码:353-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | Histone modifications regulate gene expression and development. To address how they are reprogrammed in human early development, we investigated key histone marks in human oocytes and early embryos. Unlike that in mouse oocytes, the permissive mark trimethylated histone H3 lysine 4 (H3K4me3) largely exhibits canonical patterns at promoters in human oocytes. After fertilization, prezygotic genome activation (pre-ZGA) embryos acquire permissive chromatin and widespread H3K4me3 in CpG-rich regulatory regions. By contrast, the repressive mark H3K27me3 undergoes global depletion. CpG-rich regulatory regions then resolve to either active or repressed states upon ZGA, followed by subsequent restoration of H3K27me3 at developmental genes. Finally, by combining chromatin and transcriptome maps, we revealed transcription circuitry and asymmetric H3K27me3 patterning during early lineage specification. Collectively, our data unveil a priming phase connecting human parental-to-zygotic epigenetic transition. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000477703100035 |
WOS关键词 | CHROMATIN ARCHITECTURE ; DNA ELEMENTS ; PREIMPLANTATION ; METHYLATION ; H3K4ME3 ; TROPHECTODERM ; TRANSCRIPTOME ; ENCYCLOPEDIA ; INHERITANCE ; MECHANISMS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201947 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Tsinghua Univ, Sch Life Sci, THU PKU Ctr Life Sci, Ctr Stem Cell Biol & Regenerat Med,MOE Key Lab Bi, Beijing 100084, Peoples R China; 2.Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Reprod & Genet, Ctr Reprod Med, Zhengzhou 450052, Henan, Peoples R China; 3.Tsinghua Univ, Sch Med, Ctr Stem Cell Biol & Regenerat Med, Beijing 100084, Peoples R China |
推荐引用方式 GB/T 7714 | Xia, Weikun,Xu, Jiawei,Yu, Guang,et al. Resetting histone modifications during human parental-to-zygotic transition[J]. SCIENCE,2019,365(6451):353-+. |
APA | Xia, Weikun.,Xu, Jiawei.,Yu, Guang.,Yao, Guidong.,Xu, Kai.,...&Sun, Ying-Pu.(2019).Resetting histone modifications during human parental-to-zygotic transition.SCIENCE,365(6451),353-+. |
MLA | Xia, Weikun,et al."Resetting histone modifications during human parental-to-zygotic transition".SCIENCE 365.6451(2019):353-+. |
条目包含的文件 | 条目无相关文件。 |
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