GSTDTAP  > 地球科学
DOI10.1126/science.aaw5118
Resetting histone modifications during human parental-to-zygotic transition
Xia, Weikun1; Xu, Jiawei2; Yu, Guang1; Yao, Guidong2; Xu, Kai1; Ma, Xueshan2; Zhang, Nan2; Liu, Bofeng1; Li, Tong2; Lin, Zili1; Chen, Xia3; Li, Lijia1; Wang, Qiujun1; Shi, Dayuan2; Shi, Senlin2; Zhang, Yile2; Song, Wenyan2; Jin, Haixia2; Hu, Linli2; Bu, Zhiqin2; Wang, Yang2; Na, Jie3; Xie, Wei1; Sun, Ying-Pu2
2019-07-26
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2019
卷号365期号:6451页码:353-+
文章类型Article
语种英语
国家Peoples R China
英文摘要

Histone modifications regulate gene expression and development. To address how they are reprogrammed in human early development, we investigated key histone marks in human oocytes and early embryos. Unlike that in mouse oocytes, the permissive mark trimethylated histone H3 lysine 4 (H3K4me3) largely exhibits canonical patterns at promoters in human oocytes. After fertilization, prezygotic genome activation (pre-ZGA) embryos acquire permissive chromatin and widespread H3K4me3 in CpG-rich regulatory regions. By contrast, the repressive mark H3K27me3 undergoes global depletion. CpG-rich regulatory regions then resolve to either active or repressed states upon ZGA, followed by subsequent restoration of H3K27me3 at developmental genes. Finally, by combining chromatin and transcriptome maps, we revealed transcription circuitry and asymmetric H3K27me3 patterning during early lineage specification. Collectively, our data unveil a priming phase connecting human parental-to-zygotic epigenetic transition.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000477703100035
WOS关键词CHROMATIN ARCHITECTURE ; DNA ELEMENTS ; PREIMPLANTATION ; METHYLATION ; H3K4ME3 ; TROPHECTODERM ; TRANSCRIPTOME ; ENCYCLOPEDIA ; INHERITANCE ; MECHANISMS
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/201947
专题地球科学
资源环境科学
气候变化
作者单位1.Tsinghua Univ, Sch Life Sci, THU PKU Ctr Life Sci, Ctr Stem Cell Biol & Regenerat Med,MOE Key Lab Bi, Beijing 100084, Peoples R China;
2.Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Reprod & Genet, Ctr Reprod Med, Zhengzhou 450052, Henan, Peoples R China;
3.Tsinghua Univ, Sch Med, Ctr Stem Cell Biol & Regenerat Med, Beijing 100084, Peoples R China
推荐引用方式
GB/T 7714
Xia, Weikun,Xu, Jiawei,Yu, Guang,et al. Resetting histone modifications during human parental-to-zygotic transition[J]. SCIENCE,2019,365(6451):353-+.
APA Xia, Weikun.,Xu, Jiawei.,Yu, Guang.,Yao, Guidong.,Xu, Kai.,...&Sun, Ying-Pu.(2019).Resetting histone modifications during human parental-to-zygotic transition.SCIENCE,365(6451),353-+.
MLA Xia, Weikun,et al."Resetting histone modifications during human parental-to-zygotic transition".SCIENCE 365.6451(2019):353-+.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xia, Weikun]的文章
[Xu, Jiawei]的文章
[Yu, Guang]的文章
百度学术
百度学术中相似的文章
[Xia, Weikun]的文章
[Xu, Jiawei]的文章
[Yu, Guang]的文章
必应学术
必应学术中相似的文章
[Xia, Weikun]的文章
[Xu, Jiawei]的文章
[Yu, Guang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。