Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw4361 |
Laboratory mice born to wild mice have natural microbiota and model human immune responses | |
Rosshart, Stephan P.1,12; Herz, Jasmin2; Vassallo, Brian G.1,13; Hunter, Ashli1; Wall, Morgan K.2; Badger, Jonathan H.3; McCulloch, John A.3; Anastasakis, Dimitrios G.5; Sarshad, Aishe A.5,14; Leonardi, Irina8; Collins, Nicholas4; Blatter, Joshua A.9; Han, Seong-Ji4; Tamoutounour, Samira4; Potapova, Svetlana11; St Claire, Mark B. Foster11; Yuan, Wuxing3,10; Sen, Shurjo K.3,10; Dreier, Matthew S.1; Hild, Benedikt1; Hafner, Markus5; Wang, David6,7; Iliev, Iliyan D.8; Belkaid, Yasmine4; Trinchieri, Giorgio3; Rehermann, Barbara1 | |
2019-08-02 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6452页码:461-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Germany; Sweden |
英文摘要 | Laboratory mouse studies are paramount for understanding basic biological phenomena but also have limitations. These include conflicting results caused by divergent microbiota and limited translational research value. To address both shortcomings, we transferred C57BL/6 embryos into wild mice, creating "wildlings." These mice have a natural microbiota and pathogens at all body sites and the tractable genetics of C57BL/6 mice. The bacterial microbiome, mycobiome, and virome of wildlings affect the immune landscape of multiple organs. Their gut microbiota outcompete laboratory microbiota and demonstrate resilience to environmental challenges. Wildlings, but not conventional laboratory mice, phenocopied human immune responses in two preclinical studies. A combined natural microbiota- and pathogen-based model may enhance the reproducibility of biomedical studies and increase the bench-to-bedside safety and success of immunological studies. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000485768400036 |
WOS关键词 | BACTERIAL MICROBIOME ; ANIMAL-MODELS ; T-CELLS ; MOUSE ; VIROME ; TRANSLATION ; METAGENOMICS ; ALIGNMENT ; TISSUE ; LOST |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201997 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.NIDDK, Immunol Sect, Liver Dis Branch, NIH,DHHS, Bethesda, MD 20892 USA; 2.Univ Virginia, Sch Med, Dept Neurosci, Ctr Brain Immunol & Glia, Charlottesville, VA 22908 USA; 3.NCI, Canc & Inflammat Program, Ctr Canc Res, NIH,DHHS, Bethesda, MD 20892 USA; 4.NIAID, Mucosal Immunol Sect, Lab Parasit Dis, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA; 5.NIAMSD, Lab Muscle Stem Cells & Gene Regulat, Bethesda, MD 20892 USA; 6.Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA; 7.Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA; 8.Weill Cornell Med, Jill Roberts Inst Res Inflammatory Bowel Dis, New York, NY 10021 USA; 9.Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA; 10.NCI, Leidos Biomed Res Inc, Microbiome & Genet Core, NIH, Bethesda, MD 20892 USA; 11.NIDDK, Lab Anim Sci Sect, NIH, DHHS, Bethesda, MD 20892 USA; 12.Univ Freiburg, Klin Innere Med 2, Univ Klinikum Freiburg, D-79106 Freiburg, Germany; 13.MIT, Dept Biol, 77 Massachusetts Ave,68-132, Cambridge, MA 02139 USA; 14.Univ Gothenburg, Dept Med Biochem & Cell Biol, Gothenburg, Sweden |
推荐引用方式 GB/T 7714 | Rosshart, Stephan P.,Herz, Jasmin,Vassallo, Brian G.,et al. Laboratory mice born to wild mice have natural microbiota and model human immune responses[J]. SCIENCE,2019,365(6452):461-+. |
APA | Rosshart, Stephan P..,Herz, Jasmin.,Vassallo, Brian G..,Hunter, Ashli.,Wall, Morgan K..,...&Rehermann, Barbara.(2019).Laboratory mice born to wild mice have natural microbiota and model human immune responses.SCIENCE,365(6452),461-+. |
MLA | Rosshart, Stephan P.,et al."Laboratory mice born to wild mice have natural microbiota and model human immune responses".SCIENCE 365.6452(2019):461-+. |
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