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DOI | 10.1126/science.aaw9855 |
Mitochondria-Striking a balance between host and endosymbiont | |
Youle, Richard J. | |
2019-08-16 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6454页码:655-+ |
文章类型 | Review |
语种 | 英语 |
国家 | USA |
英文摘要 | Mitochondria are organelles with their own genome that arose from alpha-proteobacteria living within single-celled Archaea more than a billion years ago. This step of endosymbiosis offered tremendous opportunities for energy production and metabolism and allowed the evolution of fungi, plants, and animals. However, less appreciated are the downsides of this endosymbiosis. Coordinating gene expression between the mitochondrial genomes and the nuclear genome is imprecise and can lead to proteotoxic stress. The clonal reproduction of mitochondrial DNA requires workarounds to avoid mutational meltdown. In metazoans that developed innate immune pathways to thwart bacterial and viral infections, mitochondrial components can cross-react with pathogen sensors and invoke inflammation. Here, I focus on the numerous and elegant quality control processes that compensate for or mitigate these challenges of endosymbiosis. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000481688700036 |
WOS关键词 | INNATE IMMUNE-RESPONSES ; NF-KAPPA-B ; STRESS-RESPONSE ; NLRP3 INFLAMMASOME ; AAA PROTEASES ; PROTEIN ; DNA ; AUTOPHAGY ; PARKIN ; MTDNA |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202090 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | NINDS, Surg Neurol Branch, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA |
推荐引用方式 GB/T 7714 | Youle, Richard J.. Mitochondria-Striking a balance between host and endosymbiont[J]. SCIENCE,2019,365(6454):655-+. |
APA | Youle, Richard J..(2019).Mitochondria-Striking a balance between host and endosymbiont.SCIENCE,365(6454),655-+. |
MLA | Youle, Richard J.."Mitochondria-Striking a balance between host and endosymbiont".SCIENCE 365.6454(2019):655-+. |
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