Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw2619 |
The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle | |
Howick, Virginia M.1; Russell, Andrew J. C.1; Andrews, Tallulah1; Heaton, Haynes1; Reid, Adam J.1; Natarajan, Kedar2; Butungi, Hellen3,4; Metcalf, Tom1; Verzier, Lisa H.1,5; Rayner, Julian C.1; Berriman, Matthew1; Herren, Jeremy K.4,6; Billker, Oliver1,7; Hemberg, Martin1; Talman, Arthur M.1,8; Lawniczak, Mara K. N.1 | |
2019-08-23 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6455页码:774-+ |
文章类型 | Article |
语种 | 英语 |
国家 | England; Denmark; Kenya; South Africa; Australia; Scotland; Sweden; France |
英文摘要 | Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments. We profiled the single-cell transcriptomes of thousands of individual parasites, deriving the first high-resolution transcriptional atlas of the entire Plasmodium berghei life cycle. We then used our atlas to precisely define developmental stages of single cells from three different human malaria parasite species, including parasites isolated directly from infected individuals. The Malaria Cell Atlas provides both a comprehensive view of gene usage in a eukaryotic parasite and an open-access reference dataset for the study of malaria parasites. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000482464000044 |
WOS关键词 | RNA-SEQ DATA ; PROTEIN ; REVEALS ; MOSQUITO ; EGRESS ; VISUALIZATION ; TRANSMISSION ; REGULATORS ; INVASION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202141 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Wellcome Sanger Inst, Wellcome Genome Campus, Cambridge CB10 1SA, England; 2.Univ Southern Denmark, Dept Biochem & Mol Biol, D IAS, Odense, Denmark; 3.Icipe, Nairobi, Kenya; 4.Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Wits Res Inst Malaria,MRC Collaborating Ctr Multi, Johannesburg, South Africa; 5.Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia; 6.MRC Univ Glasgow, Ctr Virus Res, Glasgow, Lanark, Scotland; 7.Umea Univ, Dept Mol Biol, Lab Mol Infect Med Sweden, Umea, Sweden; 8.Univ Montpellier, CNRS, MIVEGEC, IRD, Montpellier, France |
推荐引用方式 GB/T 7714 | Howick, Virginia M.,Russell, Andrew J. C.,Andrews, Tallulah,et al. The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle[J]. SCIENCE,2019,365(6455):774-+. |
APA | Howick, Virginia M..,Russell, Andrew J. C..,Andrews, Tallulah.,Heaton, Haynes.,Reid, Adam J..,...&Lawniczak, Mara K. N..(2019).The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle.SCIENCE,365(6455),774-+. |
MLA | Howick, Virginia M.,et al."The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle".SCIENCE 365.6455(2019):774-+. |
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