Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

doi:10.1126/science.aat7693

GSTDTAP > 地球科学

DOI	10.1126/science.aat7693
	Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior
	Ganna, Andrea 1,2,3,4; Verweij, Karin J. H.5; Nivard, Michel G.6; Maier, Robert 1,2,3; Wedow, Robbee 1,3,7,8,9,10,11; Busch, Alexander S.12,13,14; Abdellaoui, Abdel 5; Guo, Shengru 15; Sathirapongsasuti, J. Fah 16; Lichtenstein, Paul 4; Lundstrom, Sebastian 17; Langstrom, Niklas 4; Auton, Adam 16; Harris, Kathleen Mullan 18,19; Beecham, Gary W.15; Martin, Eden R.15; Sanders, Alan R.20,21; Perry, John R. B.12; Neale, Benjamin M.1,2,3; Zietsch, Brendan P.22; Agee, M.; Alipanahi, B.; Auton, A.; Bell, R. K.; Bryc, K.; Elson, S. L.; Fontanillas, P.; Furlotte, N. A.; Hicks, B.; Huber, K. E.; Jewett, E. M.; Jiang, Y.; Kleinman, A.; Lin, K. -H.; Litterman, N. K.; McCreight, J. C.; McIntyre, M. H.; McManus, K. F.; Mountain, J. L.; Noblin, E. S.; Northover, C. A. M.; Pitts, S. J.; Poznik, G. D.; Shastri, A. J.; Shelton, J. F.; Shringarpure, S.; Tian, C.; Tung, J. Y.; Vacic, V.; Wang, X.; Wilson, C. H.
	2019-08-30
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2019
卷号	365 期号:6456 页码:882-+
文章类型	Article
语种	英语
国家	USA; Sweden; Netherlands; England; Denmark; Australia
英文摘要	Twin and family studies have shown that same-sex sexual behavior is partly genetically influenced, but previous searches for specific genes involved have been underpowered. We performed a genome-wide association study (GWAS) on 477,522 individuals, revealing five loci significantly associated with same-sex sexual behavior. In aggregate, all tested genetic variants accounted for 8 to 25% of variation in same-sex sexual behavior, only partially overlapped between males and females, and do not allow meaningful prediction of an individual's sexual behavior. Comparing these GWAS results with those for the proportion of same-sex to total number of sexual partners among nonheterosexuals suggests that there is no single continuum from opposite-sex to same-sex sexual behavior. Overall, our findings provide insights into the genetics underlying same-sex sexual behavior and underscore the complexity of sexuality.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E ; SSCI
WOS记录号	WOS:000483975800036
WOS关键词	GENOME-WIDE ASSOCIATION ; PSYCHIATRIC-DISORDERS ; GENERAL-POPULATION ; ORIENTATION ; LINKAGE ; DISEASE ; LOCI ; SCHIZOPHRENIA ; TRAIT ; HOMOSEXUALITY
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/202202
专题	地球科学资源环境科学气候变化
作者单位	1.Massachusetts Gen Hosp, Ctr Genom Med, Analyt & Translat Genet Unit, Boston, MA 02114 USA; 2.Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA; 3.Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA; 4.Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden; 5.Univ Amsterdam, AMC, Amsterdam Univ Med Ctr UMC, Dept Psychiat, Meibergdreef 5, NL-1105 AZ Amsterdam, Netherlands; 6.Vrije Univ Amsterdam, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands; 7.Harvard Univ, Dept Sociol, Cambridge, MA 02138 USA; 8.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA; 9.Univ Colorado, Dept Sociol, Boulder, CO 80309 USA; 10.Univ Colorado, Inst Behav Sci, Hlth & Soc Program & Populat Program, Boulder, CO 80309 USA; 11.Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA; 12.Univ Cambridge, Inst Metab Sci, Sch Clin Med, MRC,Epidemiol Unit, Cambridge Biomed Campus, Cambridge, England; 13.Univ Copenhagen, Rigshosp, Dept Growth & Reprod, Copenhagen, Denmark; 14.Rigshosp, Int Ctr Res & Res Training Endocrine Disrupt Male, Copenhagen, Denmark; 15.Univ Miami, Dept Human Genet, Miami, FL 33136 USA; 16.23andMe, Mountain View, CA 94041 USA; 17.Univ Gothenburg, Gillberg Neuropsychiat Ctr, Ctr Eth Law & Mental Hlth, Gothenburg, Sweden; 18.Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC 27516 USA; 19.Univ N Carolina, Dept Sociol, Chapel Hill, NC 27599 USA; 20.NorthShore Univ HealthSyst Res Inst, Dept Psychiat & Behav Sci, Evanston, IL 60201 USA; 21.Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA; 22.Univ Queensland, Sch Psychol, Ctr Psychol & Evolut, Brisbane, Qld 4072, Australia
推荐引用方式 GB/T 7714	Ganna, Andrea,Verweij, Karin J. H.,Nivard, Michel G.,et al. Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior[J]. SCIENCE,2019,365(6456):882-+.
APA	Ganna, Andrea.,Verweij, Karin J. H..,Nivard, Michel G..,Maier, Robert.,Wedow, Robbee.,...&Wilson, C. H..(2019).Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior.SCIENCE,365(6456),882-+.
MLA	Ganna, Andrea,et al."Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior".SCIENCE 365.6456(2019):882-+.