Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw9498 |
Molecular basis and biological function of variability in spatial genome organization | |
Finn, Elizabeth H.; Misteli, Tom | |
2019-09-06 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6457页码:998-+ |
文章类型 | Review |
语种 | 英语 |
国家 | USA |
英文摘要 | The complex three-dimensional organization of genomes in the cell nucleus arises from a wide range of architectural features including DNA loops, chromatin domains, and higher-order compartments. Although these features are universally present in most cell types and tissues, recent single-cell biochemistry and imaging approaches have demonstrated stochasticity in transcription and high variability of chromatin architecture in individual cells. We review the occurrence, mechanistic basis, and functional implications of stochasticity in genome organization. We summarize recent observations on cell-and allele-specific variability of genome architecture, discuss the nature of extrinsic and intrinsic sources of variability in genome organization, and highlight potential implications of structural heterogeneity for genome function. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000484732700037 |
WOS关键词 | IMPRINTING CONTROL REGION ; CHROMATIN DECONDENSATION ; GENE-EXPRESSION ; NUCLEAR REORGANIZATION ; PHASE-SEPARATION ; CHROMOSOME ; FLUCTUATIONS ; COMPARTMENTS ; LOCI ; TRANSCRIPTOME |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202245 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | NCI, Bethesda, MD 20892 USA |
推荐引用方式 GB/T 7714 | Finn, Elizabeth H.,Misteli, Tom. Molecular basis and biological function of variability in spatial genome organization[J]. SCIENCE,2019,365(6457):998-+. |
APA | Finn, Elizabeth H.,&Misteli, Tom.(2019).Molecular basis and biological function of variability in spatial genome organization.SCIENCE,365(6457),998-+. |
MLA | Finn, Elizabeth H.,et al."Molecular basis and biological function of variability in spatial genome organization".SCIENCE 365.6457(2019):998-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论