GSTDTAP  > 地球科学
DOI10.1126/science.aax1971
A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell resolution
Packer, Jonathan S.1; Zhu, Qin2; Huynh, Chau1; Sivaramakrishnan, Priya3; Preston, Elicia3; Dueck, Hannah3,9; Stefanik, Derek4; Tan, Kai3,5,6,7,8; Trapnell, Cole1; Kim, Junhyong4; Waterston, Robert H.1; Murray, John I.3
2019-09-20
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2019
卷号365期号:6459页码:1265-+
文章类型Article
语种英语
国家USA
英文摘要

Caenorhabditis elegans is an animal with few cells but a wide diversity of cell types. In this study, we characterize the molecular basis for their specification by profiling the transcriptomes of 86,024 single embryonic cells. We identify 502 terminal and preterminal cell types, mapping most single-cell transcriptomes to their exact position in C. elegans' invariant lineage. Using these annotations, we find that (i) the correlation between a cell's lineage and its transcriptome increases from middle to late gastrulation, then falls substantially as cells in the nervous system and pharynx adopt their terminal fates; (ii) multilineage priming contributes to the differentiation of sister cells at dozens of lineage branches; and (iii) most distinct lineages that produce the same anatomical cell type converge to a homogenous transcriptomic state.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000487547400036
WOS关键词CAENORHABDITIS-ELEGANS ; GENE-EXPRESSION ; RNA-SEQ ; DIVERSITY ; INFERENCE ; NEMATODE ; EMBRYO ; GENOME ; LIM-6
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/202351
专题地球科学
资源环境科学
气候变化
作者单位1.Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA;
2.Univ Penn, Genom & Computat Biol Grad Grp, Philadelphia, PA 19104 USA;
3.Univ Penn, Dept Genet, Perelman Sch Med, Philadelphia, PA 19104 USA;
4.Univ Penn, Dept Biol, Philadelphia, PA 19104 USA;
5.Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA;
6.Childrens Hosp Philadelphia, Ctr Childhood Canc Res, Philadelphia, PA 19104 USA;
7.Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA;
8.Univ Penn, Dept Cell & Dev Biol, Perelman Sch Med, Philadelphia, PA 19104 USA;
9.NCI, Bethesda, MD 20892 USA
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GB/T 7714
Packer, Jonathan S.,Zhu, Qin,Huynh, Chau,et al. A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell resolution[J]. SCIENCE,2019,365(6459):1265-+.
APA Packer, Jonathan S..,Zhu, Qin.,Huynh, Chau.,Sivaramakrishnan, Priya.,Preston, Elicia.,...&Murray, John I..(2019).A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell resolution.SCIENCE,365(6459),1265-+.
MLA Packer, Jonathan S.,et al."A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell resolution".SCIENCE 365.6459(2019):1265-+.
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