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DOI | 10.1126/science.aat5031 |
Spatiotemporal immune zonation of the human kidney | |
Stewart, Benjamin J.1,2,3,4; Ferdinand, John R.1; Young, Matthew D.4; Mitchell, Thomas J.2,3,5; Laudon, Kevin W.1,2,3; Riding, Alexandra M.1,2,3; Richoz, Nathan1; Frazer, Gordon L.1; Staniforth, Joy U. L.1; Braga, Felipe A. Vieira4; Botting, Rachel A.6; Popeseu, Dorin-Mirel6; Vento-Tormo, Baser; Stephenson, Emily6; Cagan, Alex4; Farndon, Sarah J.7; Polanski, Krzysztof; Efremova, Mirjana; Green, Kile; Velasco-Herrera, Martin Del Castillo; Guzzo, Charlotte; Collord, Grace; Mamanova, Lira; Aho, Tevita; Armitage, James N.; Riddick, Antony C. P.; Mushtanq, Hnran7; Farrell, Stephen; Rampling, Dyamte7; Nicholson, James9; Filby, Andrew; Burge, Johanna; Lisgo, Steven10; Lindsay, Susan10; Bajenoff, Marc11; Warren, Anne Y.3; Stewart, Grant D.3; Sebire, Neil8; Coleman, Nicholas3,12; Haniffa, Muzlifah4,6,13,14; Teichmann, Sarah A.4,15; Behjati, Sam2,3,4,9; Clatworthy, Menna R.1,2,3,4 | |
2019-09-27 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6460页码:1461-+ |
文章类型 | Article |
语种 | 英语 |
国家 | England; France |
英文摘要 | Tissue-resident immune cells are important for organ homeostasis and defense. The epithelium may contribute to these functions directly or by cross-talk with immune cells. We used single-cell RNA sequencing to resolve the spatiotemporal immune topology of the human kidney. We reveal anatomically defined expression patterns of immune genes within the epithelial compartment, with antimicrobial peptide transcripts evident in pelvic epithelium in the mature. but not fetal, kidney. A network of tissue-resident myeloid and lymphoid immune cells was evident in both fetal and mature kidney, with postnatal acquisition of transcriptional programs that promote infection-defense capabilities. Epithelial-immune cross-talk orchestrated localization of antibacterial macrophages and neutrophils to the regions of the kidney most susceptible to infection. Overall, our study provides a global overview of how the immune landscape of the human kidney is zonated to counter the dominant immunological challenge. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000488838600050 |
WOS关键词 | FC-GAMMA RECEPTORS ; GENE-EXPRESSION ; DENDRITIC CELLS ; HETEROGENEITY ; MONOCYTES ; PROFILES ; IDENTITY ; SYSTEM |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202413 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Cambridge, Dept Med, Mol Immun Unit, Cambridge CB2 QQ, England; 2.Cambridge Univ Hosp NHS Fdn Trust, Cambridge CB2 OQQ, England; 3.NIHR Cambridge Biomed Res Ctr, Cambridge CB2 OQQ, England; 4.Wellcome Sanger Inst, Wlcome Genome Campus, Hinxton CB10 1SA, England; 5.Univ Cambridge, Dept Surg, Cambridge CB2 OQQ, England; 6.Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England; 7.Great Ormond St Hosp Sick Children, London WC1N 3JH, England; 8.UCL Great Ormond St Hosp Inst Child Hlth, London WC1N 1E, England; 9.Univ Cambridge, Dept Paediat, Cambridge CB2 OQQ, England; 10.Newcastle Univ, Human Dev Biol Resource, Inst Genet Med, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England; 11.Ctr Immunol Marseille Luminy, F-13009 Marseille, France; 12.Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England; 13.Newcastle Hosp NHS Fdn Trust, Dept Dermatol, Newcastle Upon Tyne NE2 4LP, Tyne & Wear, England; 14.Newcastle Hosp NHS Fdn Trust, NIHR Newcastle Biomed Res Ctr, Newcastle Upon Tyne NE2 4LP, Tyne & Wear, England; 15.Univ Cambridge, Theory Condensed Matter Grp, Cavendish Lab, Dept Phys, Cambridge CB3 OHE, England |
推荐引用方式 GB/T 7714 | Stewart, Benjamin J.,Ferdinand, John R.,Young, Matthew D.,et al. Spatiotemporal immune zonation of the human kidney[J]. SCIENCE,2019,365(6460):1461-+. |
APA | Stewart, Benjamin J..,Ferdinand, John R..,Young, Matthew D..,Mitchell, Thomas J..,Laudon, Kevin W..,...&Clatworthy, Menna R..(2019).Spatiotemporal immune zonation of the human kidney.SCIENCE,365(6460),1461-+. |
MLA | Stewart, Benjamin J.,et al."Spatiotemporal immune zonation of the human kidney".SCIENCE 365.6460(2019):1461-+. |
条目包含的文件 | 条目无相关文件。 |
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