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DOI | 10.1126/science.aay1436 |
A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis | |
Gallego-Garcia, Aranzazu1; Monera-Girona, Antonio J.1; Pajares-Martinez, Elena1; Bastida-Martinez, Eva1; Perez-Castano, Ricardo1; Iniesta, Antonio A.1; Fontes, Marta1; Padmanabhan, S.2; Elias-Arnanz, Montserrat1 | |
2019-10-04 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6461页码:128-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Spain |
英文摘要 | Plasmalogens are glycerophospholipids with a hallmark sn-1 vinyl ether bond. These lipids are found in animals and some bacteria and have proposed membrane organization, signaling, and antioxidant roles. We discovered the plasmanylethanolamine desaturase activity that is essential for vinyl ether bond formation in a bacterial enzyme, CarF, which is a homolog of the human enzyme TMEM189. CarF mediates light-induced carotenogenesis in Myxococcus xanthus, and plasmalogens participate in sensing photooxidative stress through singlet oxygen. TMEM189 and other animal homologs could functionally replace CarF in M. xanthus, and knockout of TMEM189 in a human cell line eliminated plasmalogens. Discovery of the human plasmanylethanolamine desaturase will spur further study of plasmalogen biogenesis, functions, and roles in disease. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000489147000070 |
WOS关键词 | MYXOCOCCUS-XANTHUS ; GENE-REGULATION ; ANIMAL-CELLS ; BIOSYNTHESIS ; EXPRESSION ; FAMILY ; LIPIDS ; ROLES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202450 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Murcia, Dept Genet & Microbiol, Area Genet, Unidad Asociada,Inst Quim Fis Rocasolano,CSIC,Fac, E-30100 Murcia, Spain; 2.CSIC, Inst Quim Fis Rocasolano, Plaza Murillo 2, E-28006 Madrid, Spain |
推荐引用方式 GB/T 7714 | Gallego-Garcia, Aranzazu,Monera-Girona, Antonio J.,Pajares-Martinez, Elena,et al. A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis[J]. SCIENCE,2019,366(6461):128-+. |
APA | Gallego-Garcia, Aranzazu.,Monera-Girona, Antonio J..,Pajares-Martinez, Elena.,Bastida-Martinez, Eva.,Perez-Castano, Ricardo.,...&Elias-Arnanz, Montserrat.(2019).A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis.SCIENCE,366(6461),128-+. |
MLA | Gallego-Garcia, Aranzazu,et al."A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis".SCIENCE 366.6461(2019):128-+. |
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