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DOI | 10.1126/science.aax2747 |
Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides | |
Becker, Sidney1,2; Feldmann, Jonas1; Wiedemann, Stefan1; Okamura, Hidenori1,3; Schneider, Christina1; Iwan, Katharina1,4; Crisp, Antony1; Rossa, Martin1; Amatov, Tynchtyk1,5; Carell, Thomas1 | |
2019-10-04 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6461页码:76-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; England; Japan |
英文摘要 | Theories about the origin of life require chemical pathways that allow formation of life's key building blocks under prebiotically plausible conditions. Complex molecules like RNA must have originated from small molecules whose reactivity was guided by physico-chemical processes. RNA is constructed from purine and pyrimidine nucleosides, both of which are required for accurate information transfer, and thus Darwinian evolution. Separate pathways to purines and pyrimidines have been reported, but their concurrent syntheses remain a challenge. We report the synthesis of the pyrimidine nucleosides from small molecules and ribose, driven solely by wet-dry cycles. In the presence of phosphate-containing minerals, 5'-mono- and diphosphates also form selectively in one-pot reactions. The pathway is compatible with purine synthesis, allowing the concurrent formation of all Watson-Crick bases. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000489147000059 |
WOS关键词 | ORIGIN ; NUCLEOSIDES ; PRECURSORS ; REDUCTION ; RIBOSE ; SUGARS ; BORATE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202455 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.LMU Munchen, Dept Chem, Ctr Integrated Prot Sci, Butenandtstr 5-13, D-81377 Munich, Germany; 2.Univ Cambridge, Dept Chem, Lensfield Rd, Cambridge CB2 1EW, England; 3.Tohoku Univ, Inst Multidisciplinary Res Adv Mat, Aoba Ku, 2-1-1 Katahira, Sendai, Miyagi 9808577, Japan; 4.UCL, Great Ormond St Inst Child Hlth, Ctr Translat Omics, 30 Guilford St, London WC1N 1EH, England; 5.Max Planck Inst Kohlenforsch, Kaiser Wilhelm Pl 1, D-45470 Mulheim, Germany |
推荐引用方式 GB/T 7714 | Becker, Sidney,Feldmann, Jonas,Wiedemann, Stefan,et al. Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides[J]. SCIENCE,2019,366(6461):76-+. |
APA | Becker, Sidney.,Feldmann, Jonas.,Wiedemann, Stefan.,Okamura, Hidenori.,Schneider, Christina.,...&Carell, Thomas.(2019).Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides.SCIENCE,366(6461),76-+. |
MLA | Becker, Sidney,et al."Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides".SCIENCE 366.6461(2019):76-+. |
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