GSTDTAP  > 地球科学
DOI10.1126/science.aax1522
Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula
Otsu, Y.1,8,9; Darcq, E.2; Pietrajtis, K.3; Matyas, F.4,5,6; Schwartz, E.3; Bessaih, T.3; Gerges, S. Abi3; Rousseau, C. V.1,10; Grand, T.1; Dieudonne, S.1; Paoletti, P.1; Acsady, L.4; Agulhon, C.7; Kieffer, B. L.2; Diana, M. A.3
2019-10-11
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2019
卷号366期号:6462页码:250-+
文章类型Article
语种英语
国家France; Canada; Hungary; Australia
英文摘要

The unconventional N-methyl-D-aspartate (NMDA) receptor subunits GluN3A and GluN3B can, when associated with the other glycine-binding subunit GluN1, generate excitatory conductances purely activated by glycine. However, functional GluN1/GluN3 receptors have not been identified in native adult tissues. We discovered that GluN1/GluN3A receptors are operational in neurons of the mouse adult medial habenula (MHb), an epithalamic area controlling aversive physiological states. In the absence of glycinergic neuronal specializations in the MHb, glial cells tuned neuronal activity via GluN1/GluN3A receptors. Reducing GluN1/GluN3A receptor levels in the MHb prevented place-aversion conditioning. Our study extends the physiological and behavioral implications of glycine by demonstrating its control of negatively valued emotional associations via excitatory glycinergic NMDA receptors.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000490014700046
WOS关键词T-TYPE ; CALCIUM-CHANNELS ; MICE LACKING ; SUBUNIT ; NEURONS ; HIPPOCAMPAL ; CONTRIBUTES ; MODULATION ; ACTIVATION ; RESPONSES
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/202531
专题地球科学
资源环境科学
气候变化
作者单位1.Univ PSL, Ecole Normale Super, IBENS, INSERM,CNRS,U1024,UMR8197, F-75005 Paris, France;
2.McGill Univ, Dept Psychiat, Sch Med, Douglas Hosp,Res Ctr, Verdun, PQ H4H 1R3, Canada;
3.Sorbonne Univ, CNRS, INSERM, NPS IBPS, F-75005 Paris, France;
4.Hungarian Acad Sci, Inst Expt Med, Lab Thalamus Res, H-1083 Budapest, Hungary;
5.Res Ctr Nat Sci Inst Cognit Neurosci & Psychol, H-1117 Budapest, Hungary;
6.Univ Vet Med, Dept Anat & Histol, H-1078 Budapest, Hungary;
7.Paris Descartes Univ, Glia Glia & Glia Neuron Interact Grp, Integrat Neurosci & Cognit Ctr, CNRS,UMR0O2, F-75006 Paris, France;
8.Univ Sydney, Northern Clin Sch, Kolling Inst Med Res, Pain Management Res Inst, St Leonards, NSW 2065, Australia;
9.Royal North Shore Hosp, St Leonards, NSW 2065, Australia;
10.Pasteur Inst, Neural Circuit Dynam & Decis Making, F-75015 Paris, France
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GB/T 7714
Otsu, Y.,Darcq, E.,Pietrajtis, K.,et al. Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula[J]. SCIENCE,2019,366(6462):250-+.
APA Otsu, Y..,Darcq, E..,Pietrajtis, K..,Matyas, F..,Schwartz, E..,...&Diana, M. A..(2019).Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula.SCIENCE,366(6462),250-+.
MLA Otsu, Y.,et al."Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula".SCIENCE 366.6462(2019):250-+.
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