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DOI | 10.1126/science.aay6727 |
Coordination between stochastic and deterministic specification in the Drosophila visual system | |
Courgeon, Maximilien; Desplan, Claude | |
2019-10-18 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6463页码:325-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Sensory systems use stochastic fate specification to increase their repertoire of neuronal types. How these stochastic decisions are coordinated with the development of their targets is unknown. In the Drosophila retina, two subtypes of ultraviolet-sensitive R7 photoreceptors are stochastically specified. In contrast, their targets in the brain are specified through a deterministic program. We identified subtypes of the main target of R7, the Dm8 neurons, each specific to the different subtypes of R7s. Dm8 subtypes are produced in excess by distinct neuronal progenitors, independently from R7. After matching with their cognate R7, supernumerary Dm8s are eliminated by apoptosis. Two interacting cell adhesion molecules, Dpr11 and DIP gamma, are essential for the matching of one of the synaptic pairs. These mechanisms allow the qualitative and quantitative matching of R7 and Dm8 and thereby permit the stochastic choice made in R7 to propagate to the brain. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000491290000043 |
WOS关键词 | GENE-EXPRESSION ; SPECTRAL PREFERENCE ; CELL FATE ; COLOR ; MELANOGASTER ; PATTERNS ; VISION ; LIGAND ; GROWTH |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202576 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | NYU, Dept Biol, New York, NY 10003 USA |
推荐引用方式 GB/T 7714 | Courgeon, Maximilien,Desplan, Claude. Coordination between stochastic and deterministic specification in the Drosophila visual system[J]. SCIENCE,2019,366(6463):325-+. |
APA | Courgeon, Maximilien,&Desplan, Claude.(2019).Coordination between stochastic and deterministic specification in the Drosophila visual system.SCIENCE,366(6463),325-+. |
MLA | Courgeon, Maximilien,et al."Coordination between stochastic and deterministic specification in the Drosophila visual system".SCIENCE 366.6463(2019):325-+. |
条目包含的文件 | 条目无相关文件。 |
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