Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw8848 |
Dynamic control of plant water use using designed ABA receptor agonists | |
Vaidya, Aditya S.1,2; Helander, Jonathan D. M.1,2; Peterson, Francis C.3; Elzinga, Dezi1,2; Dejonghe, Wim1,2; Kaundal, Amita1,4; Park, Sang-Youl1,2; Xing, Zenan1,2; Mega, Ryousuke5; Takeuchi, Jun6,7; Khanderahoo, Bardia1,2; Bishay, Steven1,2; Volkman, Brian F.3; Todoroki, Yasushi6,7; Okamoto, Masanori8,9; Cutler, Sean R.1,2 | |
2019-10-25 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6464页码:446-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Japan |
英文摘要 | Drought causes crop losses worldwide, and its impact is expected to increase as the world warms. This has motivated the development of small-molecule tools for mitigating the effects of drought on agriculture. We show here that current leads are limited by poor bioactivity in wheat, a widely grown staple crop, and in tomato. To address this limitation, we combined virtual screening, x-ray crystallography, and structure-guided design to develop opabactin (OP), an abscisic acid (ABA) mimic with up to an approximately sevenfold increase in receptor affinity relative to ABA and up to 10-fold greater activity in vivo. Studies in Arabidopsis thaliana reveal a role of the type III receptor PYRABACTIN RESISTANCE-LIKE 2 for the antitranspirant efficacy of OP. Thus, virtual screening and structure-guided optimization yielded newly discovered agonists for manipulating crop abiotic stress tolerance and water use. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000493177900039 |
WOS关键词 | ABSCISIC-ACID RECEPTORS ; SELECTIVE ACTIVATION ; STRUCTURE VALIDATION ; DROUGHT TOLERANCE ; MECHANISM ; BINDING ; LIGAND ; ASSOCIATION ; MOLPROBITY ; INSIGHTS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202643 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif Riverside, Inst Integrat Genome Biol, Riverside, CA 92521 USA; 2.Univ Calif Riverside, Dept Bot & Plant Sci, Riverside, CA 92521 USA; 3.Med Coll Wisconsin, Dept Biochem, Milwaukee, WI 53226 USA; 4.Utah State Univ, Dept Plants Soils & Climate, Logan, UT 84322 USA; 5.Tottori Univ, Arid Land Res Ctr, 1390 Hamasaka, Tottori 6800001, Japan; 6.Shizuoka Univ, Fac Agr, Shizuoka 4228529, Japan; 7.Shizuoka Univ, Res Inst Green Sci & Technol, Shizuoka 4228529, Japan; 8.Utsunomiya Univ, Ctr Biosci Res & Educ, 350 Mine, Utsunomiya, Tochigi 3218505, Japan; 9.Japan Sci & Technol Agcy, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan |
推荐引用方式 GB/T 7714 | Vaidya, Aditya S.,Helander, Jonathan D. M.,Peterson, Francis C.,et al. Dynamic control of plant water use using designed ABA receptor agonists[J]. SCIENCE,2019,366(6464):446-+. |
APA | Vaidya, Aditya S..,Helander, Jonathan D. M..,Peterson, Francis C..,Elzinga, Dezi.,Dejonghe, Wim.,...&Cutler, Sean R..(2019).Dynamic control of plant water use using designed ABA receptor agonists.SCIENCE,366(6464),446-+. |
MLA | Vaidya, Aditya S.,et al."Dynamic control of plant water use using designed ABA receptor agonists".SCIENCE 366.6464(2019):446-+. |
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