Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/nature21707 |
Dynamics of oligodendrocyte generation in multiple sclerosis | |
Yeung, Maggie S. Y.1; Djelloul, Mehdi1; Steiner, Embla1; Bernard, Samuel2; Salehpour, Mehran3; Possnert, Goran3; Brundin, Lou4; Frisen, Jonas1 | |
2019-02-28 | |
发表期刊 | NATURE
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ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2019 |
卷号 | 566期号:7745页码:538-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Sweden; France |
英文摘要 | Oligodendrocytes wrap nerve fibres in the central nervous system with layers of specialized cell membrane to form myelin sheaths(1). Myelin is destroyed by the immune system in multiple sclerosis, but myelin is thought to regenerate and neurological function can be recovered. In animal models of demyelinating disease, myelin is regenerated by newly generated oligodendrocytes, and remaining mature oligodendrocytes do not seem to contribute to this process(2-4). Given the major differences in the dynamics of oligodendrocyte generation and adaptive myelination between rodents and humans(5-9), it is not clear how well experimental animal models reflect the situation in multiple sclerosis. Here, by measuring the integration of C-14 derived from nuclear testing in genomic DNA(10), we assess the dynamics of oligodendrocyte generation in patients with multiple sclerosis. The generation of new oligodendrocytes was increased several-fold in normal-appearing white matter in a subset of individuals with very aggressive multiple sclerosis, but not in most subjects with the disease, demonstrating an inherent potential to substantially increase oligodendrocyte generation that fails in most patients. Oligodendrocytes in shadow plaques-thinly myelinated lesions that are thought to represent remyelinated areas-were old in patients with multiple sclerosis. The absence of new oligodendrocytes in shadow plaques suggests that remyelination of lesions occurs transiently or not at all, or that myelin is regenerated by pre-existing, and not new, oligodendrocytes in multiple sclerosis. We report unexpected oligodendrocyte generation dynamics in multiple sclerosis, and this should guide the use of current, and the development of new, therapies. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000459769100050 |
WOS关键词 | WHITE-MATTER ; PROGENITOR CELLS ; LESIONS ; NEUROGENESIS ; PATHOLOGY ; MYELINATION ; MECHANISMS ; PLASTICITY ; DAMAGE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202705 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden; 2.Univ Lyon, CNRS, UMR 5208, Inst Camille Jordan, Villeurbanne, France; 3.Uppsala Univ, Dept Phys & Astron, Ion Phys, Uppsala, Sweden; 4.Karolinska Inst, Karolinska Univ Hosp, Div Neurol, Dept Clin Neurosci, Stockholm, Sweden |
推荐引用方式 GB/T 7714 | Yeung, Maggie S. Y.,Djelloul, Mehdi,Steiner, Embla,et al. Dynamics of oligodendrocyte generation in multiple sclerosis[J]. NATURE,2019,566(7745):538-+. |
APA | Yeung, Maggie S. Y..,Djelloul, Mehdi.,Steiner, Embla.,Bernard, Samuel.,Salehpour, Mehran.,...&Frisen, Jonas.(2019).Dynamics of oligodendrocyte generation in multiple sclerosis.NATURE,566(7745),538-+. |
MLA | Yeung, Maggie S. Y.,et al."Dynamics of oligodendrocyte generation in multiple sclerosis".NATURE 566.7745(2019):538-+. |
条目包含的文件 | 条目无相关文件。 |
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