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DOI | 10.1038/nature25450 |
Allelic reprogramming of 3D chromatin architecture during early mammalian development | |
Du, Zhenhai1; Zheng, Hui1; Huang, Bo2; Ma, Rui3; Wu, Jingyi1,4; Zhang, Xianglin5,6,7; He, Jing1; Xiang, Yunlong1; Wang, Qiujun1; Li, Yuanyuan1; Ma, Jing1; Zhang, Xu5,6,7; Zhang, Ke1; Wang, Yang5,6,7; Zhang, Michael Q.5,6,7; Gao, Juntao5,6,7,8; Dixon, Jesse R.9; Wang, Xiaowo5,6,7; Zeng, Jianyang3; Xie, Wei1,4 | |
2017-07-13 | |
发表期刊 | NATURE
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ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 547期号:7662页码:232-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | In mammals, chromatin organization undergoes drastic reprogramming after fertilization(1). However, the three-dimensional structure of chromatin and its reprogramming in preimplantation development remain poorly understood. Here, by developing a low-input Hi-C (genome-wide chromosome conformation capture) approach, we examined the reprogramming of chromatin organization during early development in mice. We found that oocytes in metaphase II show homogeneous chromatin folding that lacks detectable topologically associating domains (TADs) and chromatin compartments. Strikingly, chromatin shows greatly diminished higher-order structure after fertilization. Unexpectedly, the subsequent establishment of chromatin organization is a prolonged process that extends through preimplantation development, as characterized by slow consolidation of TADs and segregation of chromatin compartments. The two sets of parental chromosomes are spatially separated from each other and display distinct compartmentalization in zygotes. Such allele separation and allelic compartmentalization can be found as late as the 8-cell stage. Finally, we show that chromatin compaction in preimplantation embryos can partially proceed in the absence of zygotic transcription and is a multi-level hierarchical process. Taken together, our data suggest that chromatin may exist in a markedly relaxed state after fertilization, followed by progressive maturation of higher-order chromatin architecture during early development. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000405314500042 |
WOS关键词 | RNA-SEQ ; PREIMPLANTATION EMBRYOS ; ZYGOTIC TRANSITION ; HUMAN GENOME ; REVEALS ; ORGANIZATION ; CHROMOSOME ; REORGANIZATION ; TRANSCRIPTION ; EXPRESSION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202834 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Tsinghua Univ, Ctr Stem Cell Biol & Regenerat Med, MOE Key Lab Bioinformat, THU PKU Ctr Life Sci,Sch Life Sci, Beijing 100084, Peoples R China; 2.Peking Univ, Acad Adv Interdisciplinary Studies, PKU THU Ctr Life Sci, Beijing 100871, Peoples R China; 3.Tsinghua Univ, Inst Interdisciplinary Informat Sci, Beijing 100084, Peoples R China; 4.Tsinghua Univ, Sch Life Sci, Joint Grad Program Peking Tsinghua NIBS, Beijing 100084, Peoples R China; 5.Tsinghua Univ, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China; 6.Tsinghua Univ, Bioinformat Div, TNLIST, Beijing 100084, Peoples R China; 7.Tsinghua Univ, Ctr Synthet & Syst Biol, Beijing 100084, Peoples R China; 8.Univ Texas Dallas, Ctr Syst Biol, Dept Biol Sci, 800 West Campbell Rd,RL11, Richardson, TX 75080 USA; 9.Salk Inst Biol Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA |
推荐引用方式 GB/T 7714 | Du, Zhenhai,Zheng, Hui,Huang, Bo,et al. Allelic reprogramming of 3D chromatin architecture during early mammalian development[J]. NATURE,2017,547(7662):232-+. |
APA | Du, Zhenhai.,Zheng, Hui.,Huang, Bo.,Ma, Rui.,Wu, Jingyi.,...&Xie, Wei.(2017).Allelic reprogramming of 3D chromatin architecture during early mammalian development.NATURE,547(7662),232-+. |
MLA | Du, Zhenhai,et al."Allelic reprogramming of 3D chromatin architecture during early mammalian development".NATURE 547.7662(2017):232-+. |
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