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DOI | 10.1038/nature25194 |
Complex pectin metabolism by gut bacteria reveals novel catalytic functions | |
Ndeh, Didier1; 39;Neill, Malcolm A.2 | |
2017-04-06 | |
发表期刊 | NATURE
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ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 544期号:7648页码:65-+ |
文章类型 | Article |
语种 | 英语 |
国家 | England; France; USA; Canada; Saudi Arabia; Ireland; South Africa |
英文摘要 | The metabolism of carbohydrate polymers drives microbial diversity in the human gut microbiota. It is unclear, however, whether bacterial consortia or single organisms are required to depolymerize highly complex glycans. Here we show that the gut bacterium Bacteroides thetaiotaomicron uses the most structurally complex glycan known: the plant pectic polysaccharide rhamnogalacturonan-II, cleaving all but 1 of its 21 distinct glycosidic linkages. The deconstruction of rhamnogalacturonan-II side chains and backbone are coordinated to overcome steric constraints, and the degradation involves previously undiscovered enzyme families and catalytic activities. The degradation system informs revision of the current structural model of rhamnogalacturonan-II and highlights how individual gut bacteria orchestrate manifold enzymes to metabolize the most challenging glycan in the human diet. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000398323300033 |
WOS关键词 | RHAMNOGALACTURONAN-II ; MACROMOLECULAR CRYSTALLOGRAPHY ; STRUCTURAL BASIS ; SIDE-CHAINS ; POLYSACCHARIDE ; MECHANISM ; MONOSACCHARIDE ; IDENTIFICATION ; MICROBIOTA ; FRAGMENTS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202836 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England; 2.Aix Marseille Univ, CNRS, Architecture & Fonct Macromol Biol, F-13288 Marseille, France; 3.INRA, UR Biopolymeres Interact Assemblages 1268, F-44300 Nantes, France; 4.John Innes Ctr, Dept Biol Chem, Norwich Res Pk, Norwich NR4 7UH, Norfolk, England; 5.Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA; 6.Univ Georgia, Complex Carbohydrate Res Ctr, 315 Riverbend Rd, Athens, GA 30602 USA; 7.Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England; 8.Lethbridge Res Ctr, Lethbridge, AB T1J 4B1, Canada; 9.INRA, USC AFMB 1408, F-13288 Marseille, France; 10.King Abdulaziz Univ, Dept Biol Sci, Jeddah, Saudi Arabia; 11.Megazyme Bray Co, Wicklow A98 YV29, Ireland; 12.Univ Stellenbosch, Dept Viticulture & Oenol, Inst Wine Biotechnol, ZA-7602 Matieland, South Africa |
推荐引用方式 GB/T 7714 | Ndeh, Didier,39;Neill, Malcolm A.. Complex pectin metabolism by gut bacteria reveals novel catalytic functions[J]. NATURE,2017,544(7648):65-+. |
APA | Ndeh, Didier,&39;Neill, Malcolm A..(2017).Complex pectin metabolism by gut bacteria reveals novel catalytic functions.NATURE,544(7648),65-+. |
MLA | Ndeh, Didier,et al."Complex pectin metabolism by gut bacteria reveals novel catalytic functions".NATURE 544.7648(2017):65-+. |
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