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DOI | 10.1038/s41586-018-0194-z |
Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche | |
Baghdadi, Meryem B.1,2,3; Castel, David4,5; Machado, Leo6; Fukada, So-ichiro7; Birk, David E.8; Relaix, Frederic6; Tajbakhsh, Shahragim1,2; Mourikis, Philippos6 | |
2018-05-31 | |
发表期刊 | NATURE |
ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2018 |
卷号 | 557期号:7707页码:714-+ |
文章类型 | Article |
语种 | 英语 |
国家 | France; Japan; USA |
英文摘要 | The cell microenvironment, which is critical for stem cell maintenance, contains both cellular and non-cellular components, including secreted growth factors and the extracellular matrix(1-3). Although Notch and other signalling pathways have previously been reported to regulate quiescence of stem cells(4-9), the composition and source of molecules that maintain the stem cell niche remain largely unknown. Here we show that adult muscle satellite (stem) cells in mice produce extracellular matrix collagens to maintain quiescence in a cell-autonomous manner. Using chromatin immunoprecipitation followed by sequencing, we identified NOTCH1/RBPJ-bound regulatory elements adjacent to specific collagen genes, the expression of which is deregulated in Notch-mutant mice. Moreover, we show that Collagen V (COLV) produced by satellite cells is a critical component of the quiescent niche, as depletion of COLV by conditional deletion of the Col5a1 gene leads to anomalous cell cycle entry and gradual diminution of the stem cell pool. Notably, the interaction of COLV with satellite cells is mediated by the Calcitonin receptor, for which COLV acts as a surrogate local ligand. Systemic administration of a calcitonin derivative is sufficient to rescue the quiescence and self-renewal defects found in COLV-null satellite cells. This study reveals a Notch-COLV-Calcitonin receptor signalling cascade that maintains satellite cells in a quiescent state in a cell-autonomous fashion, and raises the possibility that similar reciprocal mechanisms act in diverse stem cell populations. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000433412900052 |
WOS关键词 | TEMPLATE DNA STRANDS ; SATELLITE CELLS ; SELF-RENEWAL ; QUIESCENCE ; MOUSE ; DIFFERENTIATION ; TRANSCRIPTION ; REGENERATION ; MAINTENANCE ; MYOGENESIS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202913 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Inst Pasteur, Dept Dev & Stem Cell Biol, Paris, France; 2.CNRS, Inst Pasteur, UMR 3738, Paris, France; 3.Univ Paris 06, UPMC, Sorbonne Univ, Paris, France; 4.Univ Paris Saclay, Univ Paris Sud, Gustave Roussy, CNRS,UMR8203, Villejuif, France; 5.Univ Paris Saclay, Univ Paris Sud, Gustave Roussy, Dept Cancerol Enfant & Adolescent, Villejuif, France; 6.UPEC, EFS, INSERM, IMRB,U955 E10,ENVA, Creteil, France; 7.Osaka Univ, Grad Sch Pharmaceut Sci, Lab Mol & Cellular Physiol, Osaka, Japan; 8.Univ S Florida, Morsani Coll Med, Dept Mol Pharmacol & Physiol, Tampa, FL USA |
推荐引用方式 GB/T 7714 | Baghdadi, Meryem B.,Castel, David,Machado, Leo,et al. Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche[J]. NATURE,2018,557(7707):714-+. |
APA | Baghdadi, Meryem B..,Castel, David.,Machado, Leo.,Fukada, So-ichiro.,Birk, David E..,...&Mourikis, Philippos.(2018).Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche.NATURE,557(7707),714-+. |
MLA | Baghdadi, Meryem B.,et al."Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche".NATURE 557.7707(2018):714-+. |
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