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DOI | 10.1038/s41586-018-0399-1 |
uORF-mediated translation allows engineered plant disease resistance without fitness costs | |
Xu, Guoyong1; Uan, Meng Y.2; Ai, Chaoren2; Liu, Lijing1; Zhuang, Edward1; Karapetyan, Sargis1; Wang, Shiping2; Dong, Xinnian1 | |
2017-05-25 | |
发表期刊 | NATURE |
ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 545期号:7655页码:491-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Peoples R China |
英文摘要 | Controlling plant disease has been a struggle for humankind since the advent of agriculture. Studies of plant immune mechanisms have led to strategies of engineering resistant crops through ectopic transcription of plants' own defence genes, such as the master immune regulatory gene NPR1 (ref. 1). However, enhanced resistance obtained through such strategies is often associated with substantial penalties to fitness(2), making the resulting products undesirable for agricultural applications. To remedy this problem, we sought more stringent mechanisms of expressing defence proteins. On the basis of our latest finding that translation of key immune regulators, such as TBF1 (ref. 3), is rapidly and transiently induced upon pathogen challenge (see accompanying paper(4)), we developed a 'TBF1-cassette' consisting of not only the immune-inducible promoter but also two pathogen-responsive upstream open reading frames (uORFs(TBF1)) of the TBF1 gene. Here we demonstrate that inclusion of uORFs(TBF1)-mediated translational control over the production of snc1-1 (an autoactivated immune receptor) in Arabidopsis thaliana and AtNPR1 in rice enables us to engineer broad-spectrum disease resistance without compromising plant fitness in the laboratory or in the field. This broadly applicable strategy may lead to decreased pesticide use and reduce the selective pressure for resistant pathogens. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000401906500054 |
WOS关键词 | MOLECULAR-PATTERNS ; IMMUNE-SYSTEM ; RICE ; ARABIDOPSIS ; DEFENSE ; GENE ; TRANSFORMATION ; EXPRESSION ; PROTEIN ; DISSECTION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202943 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Duke Univ, Dept Biol, Howard Hughes Med Inst, Gordon & Betty Moore Fdn, Durham, NC 27708 USA; 2.Huazhong Agr Univ, Natl Ctr Plant Gene Res Wuhan, Natl Key Lab Crop Genet Improvement, Wuhan 430070, Peoples R China |
推荐引用方式 GB/T 7714 | Xu, Guoyong,Uan, Meng Y.,Ai, Chaoren,et al. uORF-mediated translation allows engineered plant disease resistance without fitness costs[J]. NATURE,2017,545(7655):491-+. |
APA | Xu, Guoyong.,Uan, Meng Y..,Ai, Chaoren.,Liu, Lijing.,Zhuang, Edward.,...&Dong, Xinnian.(2017).uORF-mediated translation allows engineered plant disease resistance without fitness costs.NATURE,545(7655),491-+. |
MLA | Xu, Guoyong,et al."uORF-mediated translation allows engineered plant disease resistance without fitness costs".NATURE 545.7655(2017):491-+. |
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