Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41586-019-1436-4 |
Kinase-controlled phase transition of membraneless organelles in mitosis | |
Rai, Arpan Kumar1; Chen, Jia-Xuan2,4; Selbach, Matthias2,3; Pelkmans, Lucas1 | |
2019-08-21 | |
发表期刊 | NATURE |
ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2018 |
卷号 | 559期号:7713页码:211-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland; Germany; England |
英文摘要 | Liquid-liquid phase separation has been shown to underlie the formation and disassembly of membraneless organelles in cells, but the cellular mechanisms that control this phenomenon are poorly understood. A prominent example of regulated and reversible segregation of liquid phases may occur during mitosis, when membraneless organelles disappear upon nuclear-envelope breakdown and reappear as mitosis is completed. Here we show that the dual-specificity kinase DYRK3 acts as a central dissolvase of several types of membraneless organelle during mitosis. DYRK3 kinase activity is essential to prevent the unmixing of the mitotic cytoplasm into aberrant liquid-like hybrid organelles and the over-nucleation of spindle bodies. Our work supports a mechanism in which the dilution of phase-separating proteins during nuclear-envelope breakdown and the DYRK3-dependent degree of their solubility combine to allow cells to dissolve and condense several membraneless organelles during mitosis. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000438240900047 |
WOS关键词 | TO-EMBRYO TRANSITION ; CELL-CYCLE ; PROTEIN ; GRANULES ; ANAPHASE ; PHOSPHORYLATION ; LOCALIZATION ; KINETOCHORE ; PROTEOMICS ; MECHANISM |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203100 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Zurich, Dept Mol Life Sci, Zurich, Switzerland; 2.Max Delbruck Ctr Mol Med, Berlin, Germany; 3.Charite Univ Med Berlin, Berlin, Germany; 4.Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England |
推荐引用方式 GB/T 7714 | Rai, Arpan Kumar,Chen, Jia-Xuan,Selbach, Matthias,et al. Kinase-controlled phase transition of membraneless organelles in mitosis[J]. NATURE,2019,559(7713):211-+. |
APA | Rai, Arpan Kumar,Chen, Jia-Xuan,Selbach, Matthias,&Pelkmans, Lucas.(2019).Kinase-controlled phase transition of membraneless organelles in mitosis.NATURE,559(7713),211-+. |
MLA | Rai, Arpan Kumar,et al."Kinase-controlled phase transition of membraneless organelles in mitosis".NATURE 559.7713(2019):211-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论