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DOI | 10.1038/ncomms14062 |
Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media | |
Latreille, Pierre-Luc1; Adibnia, Vahid1; Nour, Antone1,3; Rabanel, Jean-Michel1,4; Lalloz, Augustine1; Arlt, Jochen2; Poon, Wilson C. K.2; Hildgen, Patrice1; Martinez, Vincent A.2; Banquyf, Xavier1 | |
2019-09-20 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Canada; Scotland |
英文摘要 | Improving nanoparticles (NPs) transport across biological barriers is a significant challenge that could be addressed through understanding NPs diffusion in dense and confined media. Here, we report the ability of soft NPs to shrink in confined environments, therefore boosting their diffusion compared to hard, non-deformable particles. We demonstrate this behavior by embedding microgel NPs in agarose gels. The origin of the shrinking appears to be related to the overlap of the electrostatic double layers (EDL) surrounding the NPs and the agarose fibres. Indeed, it is shown that screening the EDL interactions, by increasing the ionic strength of the medium, prevents the soft particle shrinkage. The shrunken NPs diffuse up to 2 orders of magnitude faster in agarose gel than their hard NP counterparts. These findings provide valuable insights on the role of long range interactions on soft NPs dynamics in crowded environments, and help rationalize the design of more efficient NP-based transport systems. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000486995200004 |
WOS关键词 | GELATION MECHANISM ; POLYMER ; CIRCULATION ; MICROSCOPY ; TRANSPORT ; SIZE ; INCLUSION ; HYDROGELS ; NANOGELS ; PARTICLE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203162 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Montreal, Fac Pharm, POB 6128,Succursale Ctr Ville, Montreal, PQ H3C 3J7, Canada; 2.Univ Edinburgh, Sch Phys & Astron, Peter Guthrie Tait Rd, Edinburgh EH9 3FD, Midlothian, Scotland; 3.McGill Univ, Injury Repair Recovery Program, Dept Surg, Div Orthopaed,Res Inst,Hlth Ctr, Montreal, PQ, Canada; 4.INRS Inst Armand Frappier, Res Ctr, 531 Boul Prairies, Laval, PQ H7V 1B7, Canada |
推荐引用方式 GB/T 7714 | Latreille, Pierre-Luc,Adibnia, Vahid,Nour, Antone,et al. Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Latreille, Pierre-Luc.,Adibnia, Vahid.,Nour, Antone.,Rabanel, Jean-Michel.,Lalloz, Augustine.,...&Banquyf, Xavier.(2019).Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media.NATURE COMMUNICATIONS,10. |
MLA | Latreille, Pierre-Luc,et al."Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
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