GSTDTAP  > 资源环境科学
DOI10.1038/ncomms14062
Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media
Latreille, Pierre-Luc1; Adibnia, Vahid1; Nour, Antone1,3; Rabanel, Jean-Michel1,4; Lalloz, Augustine1; Arlt, Jochen2; Poon, Wilson C. K.2; Hildgen, Patrice1; Martinez, Vincent A.2; Banquyf, Xavier1
2019-09-20
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
出版年2019
卷号10
文章类型Article
语种英语
国家Canada; Scotland
英文摘要

Improving nanoparticles (NPs) transport across biological barriers is a significant challenge that could be addressed through understanding NPs diffusion in dense and confined media. Here, we report the ability of soft NPs to shrink in confined environments, therefore boosting their diffusion compared to hard, non-deformable particles. We demonstrate this behavior by embedding microgel NPs in agarose gels. The origin of the shrinking appears to be related to the overlap of the electrostatic double layers (EDL) surrounding the NPs and the agarose fibres. Indeed, it is shown that screening the EDL interactions, by increasing the ionic strength of the medium, prevents the soft particle shrinkage. The shrunken NPs diffuse up to 2 orders of magnitude faster in agarose gel than their hard NP counterparts. These findings provide valuable insights on the role of long range interactions on soft NPs dynamics in crowded environments, and help rationalize the design of more efficient NP-based transport systems.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000486995200004
WOS关键词GELATION MECHANISM ; POLYMER ; CIRCULATION ; MICROSCOPY ; TRANSPORT ; SIZE ; INCLUSION ; HYDROGELS ; NANOGELS ; PARTICLE
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/203162
专题资源环境科学
作者单位1.Univ Montreal, Fac Pharm, POB 6128,Succursale Ctr Ville, Montreal, PQ H3C 3J7, Canada;
2.Univ Edinburgh, Sch Phys & Astron, Peter Guthrie Tait Rd, Edinburgh EH9 3FD, Midlothian, Scotland;
3.McGill Univ, Injury Repair Recovery Program, Dept Surg, Div Orthopaed,Res Inst,Hlth Ctr, Montreal, PQ, Canada;
4.INRS Inst Armand Frappier, Res Ctr, 531 Boul Prairies, Laval, PQ H7V 1B7, Canada
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GB/T 7714
Latreille, Pierre-Luc,Adibnia, Vahid,Nour, Antone,et al. Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media[J]. NATURE COMMUNICATIONS,2019,10.
APA Latreille, Pierre-Luc.,Adibnia, Vahid.,Nour, Antone.,Rabanel, Jean-Michel.,Lalloz, Augustine.,...&Banquyf, Xavier.(2019).Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media.NATURE COMMUNICATIONS,10.
MLA Latreille, Pierre-Luc,et al."Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media".NATURE COMMUNICATIONS 10(2019).
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