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DOI | 10.1038/ncomms14590 |
Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction | |
Zhang, Fu-Ping1,2; Malinen, Marjo3; Mehmood, Arfa4,5; Lehtiniemi, Tiina1; Jaaskelainen, Tiina6; Niskanen, Einari A.6; Korhonen, Hanna1; Laiho, Asta4,5; Elo, Laura L.4,5; Ohlsson, Claes7; Kotaja, Noora1; Poutanen, Matti1,2,7; Sipila, Petra1,2; Palvimo, Jorma J.6 | |
2019-02-15 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Finland; Sweden |
英文摘要 | Androgen receptor (AR) is regulated by SUMOylation at its transactivation domain. In vitro, the SUMOylation is linked to transcriptional repression and/or target gene-selective regulation. Here, we generated a mouse model (ArKl) in which the conserved SUMO acceptor lysines of AR are permanently abolished (Ar-K381R, (K500R)) ArKl males develop normally, without apparent defects in their systemic androgen action in reproductive tissues. However, the ArKl males are infertile. Their spermatogenesis appears unaffected, but their epididymal sperm maturation is defective, shown by severely compromised motility and fertilization capacity of the sperm. Fittingly, their epididymal AR chromatin-binding and gene expression associated with sperm maturation and function are misregulated. AR is SUMOylated in the wild-type epididymis but not in the testis, which could explain the tissue-specific response to the lack of AR SUMOylation. Our studies thus indicate that epididymal AR SUMOylation is essential for the post-testicular sperm maturation and normal reproductive capability of male mice. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000458755000003 |
WOS关键词 | MOUSE EPIDIDYMIS ; RESPONSE ELEMENT ; GENE ; SUMO ; UBIQUITIN ; BIOCONDUCTOR ; INTEGRITY ; PATHWAY ; HEALTH ; FAMILY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203214 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Turku, Res Ctr Integrat Physiol & Pharmacol, Inst Biomed, FI-20520 Turku, Finland; 2.Univ Turku, TCDM, Inst Biomed, FI-20520 Turku, Finland; 3.Univ Eastern Finland, Dept Environm & Biol Sci, FI-80101 Joensuu, Finland; 4.Univ Turku, Turku Ctr Biotechnol, FI-20014 Turku, Finland; 5.Abo Akad Univ, FI-20014 Turku, Finland; 6.Univ Eastern Finland, Inst Biomed, FI-70211 Kuopio, Finland; 7.Gothenburg Univ, Sahlgrenska Acad, Inst Med, S-41345 Gothenburg, Sweden |
推荐引用方式 GB/T 7714 | Zhang, Fu-Ping,Malinen, Marjo,Mehmood, Arfa,et al. Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Zhang, Fu-Ping.,Malinen, Marjo.,Mehmood, Arfa.,Lehtiniemi, Tiina.,Jaaskelainen, Tiina.,...&Palvimo, Jorma J..(2019).Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction.NATURE COMMUNICATIONS,10. |
MLA | Zhang, Fu-Ping,et al."Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction".NATURE COMMUNICATIONS 10(2019). |
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