Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/ncomms14376 |
Estimating dispensable content in the human interactome | |
Ghadie, Mohamed; Xia, Yu | |
2019-07-19 | |
发表期刊 | NATURE COMMUNICATIONS
![]() |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Canada |
英文摘要 | Protein-protein interaction (PPI) networks (interactome networks) have successfully advanced our knowledge of molecular function, disease and evolution. While much progress has been made in quantifying errors and biases in experimental PPI datasets, it remains unknown what fraction of the error-free PPIs in the cell are completely dispensable, i.e., effectively neutral upon disruption. Here, we estimate dispensable content in the human interactome by calculating the fractions of PPIs disrupted by neutral and non-neutral mutations. Starting with the human reference interactome determined by experiments, we construct a human structural interactome by building homology-based three-dimensional structural models for PPIs. Next, we map common mutations from healthy individuals as well as Mendelian disease-causing mutations onto the human structural interactome, and perform structure-based calculations of how these mutations perturb the interactome. Using our predicted as well as experimentally-determined interactome perturbation patterns by common and disease mutations, we estimate that |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000476471300014 |
WOS关键词 | OF-FUNCTION MUTATIONS ; PROTEIN ; EVOLUTION ; NETWORKS ; DISEASE ; PHOSPHORYLATION ; PRINCIPLES ; GENOTYPE ; DATABASE ; INSIGHT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203231 |
专题 | 资源环境科学 |
作者单位 | McGill Univ, Dept Bioengn, Montreal, PQ, Canada |
推荐引用方式 GB/T 7714 | Ghadie, Mohamed,Xia, Yu. Estimating dispensable content in the human interactome[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Ghadie, Mohamed,&Xia, Yu.(2019).Estimating dispensable content in the human interactome.NATURE COMMUNICATIONS,10. |
MLA | Ghadie, Mohamed,et al."Estimating dispensable content in the human interactome".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
个性服务 |
推荐该条目 |
保存到收藏夹 |
查看访问统计 |
导出为Endnote文件 |
谷歌学术 |
谷歌学术中相似的文章 |
[Ghadie, Mohamed]的文章 |
[Xia, Yu]的文章 |
百度学术 |
百度学术中相似的文章 |
[Ghadie, Mohamed]的文章 |
[Xia, Yu]的文章 |
必应学术 |
必应学术中相似的文章 |
[Ghadie, Mohamed]的文章 |
[Xia, Yu]的文章 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论