Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/ncomms14668 |
Mutation bias and GC content shape antimutator invasions | |
Couce, Alejandro1,2; Tenaillon, Olivier1 | |
2019-07-15 | |
发表期刊 | NATURE COMMUNICATIONS
![]() |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | France; England |
英文摘要 | Mutators represent a successful strategy in rapidly adapting asexual populations, but theory predicts their eventual extinction due to their unsustainably large deleterious load. While antimutator invasions have been documented experimentally, important discrepancies among studies remain currently unexplained. Here we show that a largely neglected factor, the mutational idiosyncrasy displayed by different mutators, can play a major role in this process. Analysing phylogenetically diverse bacteria, we find marked and systematic differences in the protein-disruptive effects of mutations caused by different mutators in species with different GC compositions. Computer simulations show that these differences can account for order-of-magnitude changes in antimutator fitness for a realistic range of parameters. Overall, our results suggest that antimutator dynamics may be highly dependent on the specific genetic, ecological and evolutionary history of a given population. This context-dependency further complicates our understanding of mutators in clinical settings, as well as their role in shaping bacterial genome size and composition. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000475469400005 |
WOS关键词 | ESCHERICHIA-COLI ; HORIZONTAL TRANSFER ; NUCLEOTIDE SUBSTITUTIONS ; FIXATION PROBABILITY ; EVOLUTION ; FITNESS ; RATES ; SELECTION ; MUTATORS ; POPULATIONS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203236 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Paris Diderot, INSERM, IAME, Unite Mixte Rech 1137, F-75018 Paris, France; 2.Imperial Coll London, Dept Life Sci, London SW7 2AZ, England |
推荐引用方式 GB/T 7714 | Couce, Alejandro,Tenaillon, Olivier. Mutation bias and GC content shape antimutator invasions[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Couce, Alejandro,&Tenaillon, Olivier.(2019).Mutation bias and GC content shape antimutator invasions.NATURE COMMUNICATIONS,10. |
MLA | Couce, Alejandro,et al."Mutation bias and GC content shape antimutator invasions".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论