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DOI | 10.1038/ncomms14790 |
Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins | |
Wirth, Martina1; 39;Reilly, Nicola2 | |
2019-05-03 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | England; Norway |
英文摘要 | Autophagy is an essential recycling and quality control pathway. Mammalian ATG8 proteins drive autophagosome formation and selective removal of protein aggregates and organelles by recruiting autophagy receptors and adaptors that contain a LC3-interacting region (LIR) motif. LIR motifs can be highly selective for ATG8 subfamily proteins (LC3s/GABARAPs), however the molecular determinants regulating these selective interactions remain elusive. Here we show that residues within the core LIR motif and adjacent C-terminal region as well as ATG8 subfamily-specific residues in the LIR docking site are critical for binding of receptors and adaptors to GABARAPs. Moreover, rendering GABARAP more LC3B-like impairs autophagy receptor degradation. Modulating LIR binding specificity of the centriolar satellite protein PCM1, implicated in autophagy and centrosomal function, alters its dynamics in cells. Our data provides new mechanistic insight into how selective binding of LIR motifs to GABARAPs is achieved, and elucidate the overlapping and distinct functions of ATG8 subfamily proteins. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000466699900014 |
WOS关键词 | CENTRIOLAR SATELLITE INTEGRITY ; LIR MOTIF ; STRUCTURAL BASIS ; LC3 ; RECOGNITION ; FYCO1 ; COMPLEX ; SYSTEM ; KINASE ; CILIOGENESIS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203262 |
专题 | 资源环境科学 |
作者单位 | 1.Francis Crick Inst, Mol Cell Biol Autophagy, 1 Midland Rd, London NW1 1AT, England; 2.Francis Crick Inst, Struct Biol Sci Technol Platforms, 1 Midland Rd, London NW1 1AT, England; 3.Francis Crick Inst, Peptide Chem Sci Technol Platforms, 1 Midland Rd, London NW1 1AT, England; 4.Univ Tromso, Dept Med Biol, Mol Canc Res Grp, N-9037 Tromso, Norway |
推荐引用方式 GB/T 7714 | Wirth, Martina,39;Reilly, Nicola. Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Wirth, Martina,&39;Reilly, Nicola.(2019).Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins.NATURE COMMUNICATIONS,10. |
MLA | Wirth, Martina,et al."Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins".NATURE COMMUNICATIONS 10(2019). |
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