Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling

doi:10.1038/ncomms15548

GSTDTAP > 资源环境科学

DOI	10.1038/ncomms15548
	Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling
	Hamnett, Ryan 1,2; Crosby, Priya 1; Chesham, Johanna E.1; Hastings, Michael H.1
	2019-02-01
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
出版年	2019
卷号	10
文章类型	Article
语种	英语
国家	England; USA
英文摘要	The suprachiasmatic nucleus (SCN) co-ordinates circadian behaviour and physiology in mammals. Its cell-autonomous circadian oscillations pivot around a well characterised transcriptional/translational feedback loop (TTFL), whilst the SCN circuit as a whole is synchronised to solar time by its retinorecipient cells that express and release vasoactive intestinal peptide (VIP). The cell-autonomous and circuit-level mechanisms whereby VIP synchronises the SCN are poorly understood. We show that SCN slices in organotypic culture demonstrate rapid and sustained circuit-level circadian responses to VIP that are mediated at a cell-autonomous level. This is accompanied by changes across a broad transcriptional network and by significant VIP-directed plasticity in the internal phasing of the cell-autonomous TTFL. Signalling via ERK1/2 and tuning by its negative regulator DUSP4 are critical elements of the VIP-directed circadian re-programming. In summary, we provide detailed mechanistic insight into VIP signal transduction in the SCN at the level of genes, cells and neural circuit.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000457440700007
WOS关键词	FUNCTIONAL-ANALYSIS ; VPAC(2) RECEPTOR ; CELLULAR CLOCKS ; GENE-EXPRESSION ; PHOTIC INPUT ; PHASE-SHIFTS ; IN-VITRO ; NUCLEUS ; LIGHT ; ENTRAINMENT
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/203311
专题	资源环境科学
作者单位	1.MRC Lab Mol Biol, Francis Crick Ave, Cambridge CB2 0QH, England; 2.Stanford Univ, Dept Neurosurg, 318 Campus Dr, Stanford, CA 94305 USA
推荐引用方式 GB/T 7714	Hamnett, Ryan,Crosby, Priya,Chesham, Johanna E.,et al. Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling[J]. NATURE COMMUNICATIONS,2019,10.
APA	Hamnett, Ryan,Crosby, Priya,Chesham, Johanna E.,&Hastings, Michael H..(2019).Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling.NATURE COMMUNICATIONS,10.
MLA	Hamnett, Ryan,et al."Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling".NATURE COMMUNICATIONS 10(2019).