Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/ncomms15416 |
A chemo-enzymatic oxidation cascade to activate C-H bonds with in situ generated H2O2 | |
Freakley, Simon J.1,2; Kochius, Svenja3,4; van Marwijk, Jacqueline3,4; Fenner, Caryn4,5; Lewis, Richard J.1; Baldenius, Kai6; Marais, Sarel S.3,4; Opperman, Diederik J.3,4; Harrison, Susan T. L.4,5; Alcalde, Miguel7; Smit, Martha S.3,4; Hutchings, Graham J.1 | |
2019-09-13 | |
发表期刊 | NATURE COMMUNICATIONS
![]() |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Wales; England; South Africa; Germany; Spain |
英文摘要 | Continuous low-level supply or in situ generation of hydrogen peroxide (H2O2) is essential for the stability of unspecific peroxygenases, which are deemed ideal biocatalysts for the selective activation of C-H bonds. To envisage potential large scale applications of combined catalytic systems the reactions need to be simple, efficient and produce minimal by-products. We show that gold-palladium nanoparticles supported on TiO2 or carbon have sufficient activity at ambient temperature and pressure to generate H2O2 from H-2 and O-2 and supply the oxidant to the engineered unspecific heme-thiolate peroxygenase PaDa-I. This tandem catalyst combination facilitates efficient oxidation of a range of C-H bonds to hydroxylated products in one reaction vessel with only water as a by-product under conditions that could be easily scaled. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000485685900017 |
WOS关键词 | CYCLOHEXANE OXIDATION ; HYDROGEN-PEROXIDE ; UNSPECIFIC PEROXYGENASE ; CATALYST ; INACTIVATION ; ISOPHORONE ; SYSTEM |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203322 |
专题 | 资源环境科学 |
作者单位 | 1.Cardiff Univ, Sch Chem, Cardiff Catalysis Inst, Main Bldg,Pk Pl, Cardiff CF10 3AT, S Glam, Wales; 2.Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England; 3.Univ Free State, Dept Microbial Biochem & Food Biotechnol, Bloemfontein, South Africa; 4.Univ Cape Town, C Change, South African DST NRF Ctr Excellence Catalysis, ZA-7701 Cape Town, South Africa; 5.Univ Cape Town, Dept Chem Engn, Ctr Bioproc Engn Res CeBER, Private Bag X3, ZA-7701 Cape Town, South Africa; 6.BASF SE, RBW OS A 30, Carl Bosch Str 38, D-67056 Ludwigshafen, Germany; 7.CSIC, Inst Catalysis, Dept Biocatalysis, E-28049 Madrid, Spain |
推荐引用方式 GB/T 7714 | Freakley, Simon J.,Kochius, Svenja,van Marwijk, Jacqueline,et al. A chemo-enzymatic oxidation cascade to activate C-H bonds with in situ generated H2O2[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Freakley, Simon J..,Kochius, Svenja.,van Marwijk, Jacqueline.,Fenner, Caryn.,Lewis, Richard J..,...&Hutchings, Graham J..(2019).A chemo-enzymatic oxidation cascade to activate C-H bonds with in situ generated H2O2.NATURE COMMUNICATIONS,10. |
MLA | Freakley, Simon J.,et al."A chemo-enzymatic oxidation cascade to activate C-H bonds with in situ generated H2O2".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论