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DOI | 10.1038/ncomms15707 |
SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target | |
Yuan, Shuofeng1,2; Chu, Hin1,2; Chan, Jasper Fuk-Woo1,2,3,4,5; Ye, Zi-Wei2; Wen, Lei2; Yan, Bingpeng2; Lai, Pok-Man2; Tee, Kah-Meng2; Huang, Jingjing2; Chen, Dongdong2; Li, Cun2; Zhao, Xiaoyu2; Yang, Dong2,7; Chiu, Man Chun2; Yip, Cyril2; Poon, Vincent Kwok-Man2; Chan, Chris Chung-Sing2; Sze, Kong-Hung1,2; Zhou, Jie1,2; Chan, Ivy Hau-Yee6; Kok, Kin-Hang1,2,3; To, Kelvin Kai-Wang1,2,3,4; Kao, Richard Yi-Tsun1,2,3; Lau, Johnson Yiu-Nam3; Jin, Dong-Yan; Perlman, Stanley8,9; Yuen, Kwok-Yung1,2,3,4,5,10 | |
2019-01-10 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | Viruses are obligate intracellular microbes that exploit the host metabolic machineries to meet their biosynthetic demands, making these host pathways potential therapeutic targets. Here, by exploring a lipid library, we show that AM580, a retinoid derivative and RAR-alpha agonist, is highly potent in interrupting the life cycle of diverse viruses including Middle East respiratory syndrome coronavirus and influenza A virus. Using click chemistry, the over-expressed sterol regulatory element binding protein (SREBP) is shown to interact with AM580, which accounts for its broad-spectrum antiviral activity. Mechanistic studies pinpoint multiple SREBP proteolytic processes and SREBP-regulated lipid biosynthesis pathways, including the downstream viral protein palmitoylation and double-membrane vesicles formation, that are indispensable for virus replication. Collectively, our study identifies a basic lipogenic transactivation event with broad relevance to human viral infections and represents SREBP as a potential target for the development of broad-spectrum antiviral strategies. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000455354800017 |
WOS关键词 | RESPIRATORY SYNDROME CORONAVIRUS ; FATTY-ACID SYNTHESIS ; INFLUENZA-A H5N1 ; SMALL-MOLECULE ; VIRAL REPLICATION ; METABOLOMIC DATA ; VIRUS ; BINDING ; PROTEIN ; IDENTIFICATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203328 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Hong Kong, Li Ka Shing Fac Med, State Key Lab Emerging Infect Dis, Pokfulam, Hong Kong, Peoples R China; 2.Univ Hong Kong, Li Ka Shing Fac Med, Dept Microbiol, Pokfulam, Hong Kong, Peoples R China; 3.Univ Hong Kong, Li Ka Shing Fac Med, Carol Yu Ctr Infect, Pokfulam, Hong Kong, Peoples R China; 4.Univ Hong Kong, Shenzhen Hosp, Dept Clin Microbiol & Infect Control, Shenzhen 518000, Peoples R China; 5.Hainan Med Univ, Hainan Med Univ Univ Hong Kong Joint Lab Trop Inf, Haikou 570100, Hainan, Peoples R China; 6.Univ Hong Kong, Li Ka Shing Fac Med, Dept Surg, Pokfulam, Hong Kong, Peoples R China; 7.Univ Hong Kong, Sch Biomed Sci, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China; 8.Univ Iowa, Dept Microbiol & Immunol, Iowa City, IA 52242 USA; 9.Guangzhou Med Univ, Guangzhou Inst Resp Hlth, Natl Clin Res Ctr Resp Dis, State Key Lab Resp Dis,Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R China; 10.Univ Hong Kong, Li Ka Shing Fac Med, Collaborat Innovat Ctr Diag & Treatment Infect Di, Pokfulam, Hong Kong, Peoples R China |
推荐引用方式 GB/T 7714 | Yuan, Shuofeng,Chu, Hin,Chan, Jasper Fuk-Woo,et al. SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Yuan, Shuofeng.,Chu, Hin.,Chan, Jasper Fuk-Woo.,Ye, Zi-Wei.,Wen, Lei.,...&Yuen, Kwok-Yung.(2019).SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target.NATURE COMMUNICATIONS,10. |
MLA | Yuan, Shuofeng,et al."SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target".NATURE COMMUNICATIONS 10(2019). |
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