Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/ncomms15647 |
Maintenance of cell type-specific connectivity and circuit function requires Tao kinase | |
Tenedini, Federico Marcello1; Gonzalez, Maria Saez1; Hu, Chun1; Pedersen, Lisa Hedegaard1; Petruzzi, Mabel Matamala1; Spitzweck, Bettina1; Wang, Denan1; Richter, Melanie2; Petersen, Meike1; Szpotowicz, Emanuela3; Schweizer, Michaela3; Sigrist, Stephan J.4; de Anda, Froylan Calderon2; Soba, Peter1 | |
2019-08-05 | |
发表期刊 | NATURE COMMUNICATIONS
![]() |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany |
英文摘要 | Sensory circuits are typically established during early development, yet how circuit specificity and function are maintained during organismal growth has not been elucidated. To gain insight we quantitatively investigated synaptic growth and connectivity in the Drosophila nociceptive network during larval development. We show that connectivity between primary nociceptors and their downstream neurons scales with animal size. We further identified the conserved Ste20-like kinase Tao as a negative regulator of synaptic growth required for maintenance of circuit specificity and connectivity. Loss of Tao kinase resulted in exuberant postsynaptic specializations and aberrant connectivity during larval growth. Using functional imaging and behavioral analysis we show that loss of Tao-induced ectopic synapses with inappropriate partner neurons are functional and alter behavioral responses in a connection-specific manner. Our data show that fine-tuning of synaptic growth by Tao kinase is required for maintaining specificity and behavioral output of the neuronal network during animal growth. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000478746200001 |
WOS关键词 | GANGLION-CELLS ; SYNAPTIC PLASTICITY ; DENDRITIC GROWTH ; NEURAL CIRCUITS ; NERVOUS-SYSTEM ; DROSOPHILA ; NEURONS ; MECHANISMS ; RECEPTOR ; NOMPC |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203337 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Med Ctr Hamburg Eppendorf, Ctr Mol Neurobiol ZMNH, Neuronal Patterning & Connect Lab, Falkenried 94, D-20251 Hamburg, Germany; 2.Univ Med Ctr Hamburg Eppendorf, Ctr Mol Neurobiol ZMNH, Neuronal Dev Lab, Falkenried 94, D-20251 Hamburg, Germany; 3.Univ Med Ctr Hamburg Eppendorf, Ctr Mol Neurobiol ZMNH, Electron Microscopy Unit, Falkenried 94, D-20251 Hamburg, Germany; 4.Free Univ Berlin, Inst Biol, Takustr 6, D-14195 Berlin, Germany |
推荐引用方式 GB/T 7714 | Tenedini, Federico Marcello,Gonzalez, Maria Saez,Hu, Chun,et al. Maintenance of cell type-specific connectivity and circuit function requires Tao kinase[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Tenedini, Federico Marcello.,Gonzalez, Maria Saez.,Hu, Chun.,Pedersen, Lisa Hedegaard.,Petruzzi, Mabel Matamala.,...&Soba, Peter.(2019).Maintenance of cell type-specific connectivity and circuit function requires Tao kinase.NATURE COMMUNICATIONS,10. |
MLA | Tenedini, Federico Marcello,et al."Maintenance of cell type-specific connectivity and circuit function requires Tao kinase".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论