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DOI | 10.1038/ncomms15472 |
Evidence for model-based encoding of Pavlovian contingencies in the human brain | |
Pauli, Wolfgang M.1; 39;Doherty, John P.2 | |
2019-03-07 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Prominent accounts of Pavlovian conditioning successfully approximate the frequency and intensity of conditioned responses under the assumption that learning is exclusively model-free; that animals do not develop a cognitive map of events. However, these model-free approximations fall short of comprehensively capturing learning and behavior in Pavlovian conditioning. We therefore performed multivoxel pattern analysis of high-resolution functional MRI data in human participants to test for the encoding of stimulus-stimulus associations that could support model-based computations during Pavlovian conditioning. We found that dissociable sub-regions of the striatum encode predictions of stimulus-stimulus associations and predictive value, in a manner that is directly related to learning performance. Activity patterns in the orbitofrontal cortex were also found to be related to stimulus-stimulus as well as value encoding. These results suggest that the brain encodes model-based representations during Pavlovian conditioning, and that these representations are utilized in the service of behavior. |
领域 | 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000460509900001 |
WOS关键词 | TEMPORAL DIFFERENCE MODELS ; ANTERIOR CINGULATE CORTEX ; NUCLEUS-ACCUMBENS CORE ; ORBITOFRONTAL CORTEX ; DORSOLATERAL STRIATUM ; DOPAMINE RELEASE ; REWARD ; AMYGDALA ; INFORMATION ; PREDICTION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203338 |
专题 | 资源环境科学 |
作者单位 | 1.CALTECH, Div Humanities & Social Sci, MC 228-77,1200 E Calif Blvd, Pasadena, CA 91125 USA; 2.CALTECH, Computat & Neural Syst Program, MC 228-77,1200 E Calif Blvd, Pasadena, CA 91125 USA; 3.Microsoft, Artificial Intelligence Platform, One Microsoft Way, Redmond, WA 98052 USA |
推荐引用方式 GB/T 7714 | Pauli, Wolfgang M.,39;Doherty, John P.. Evidence for model-based encoding of Pavlovian contingencies in the human brain[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Pauli, Wolfgang M.,&39;Doherty, John P..(2019).Evidence for model-based encoding of Pavlovian contingencies in the human brain.NATURE COMMUNICATIONS,10. |
MLA | Pauli, Wolfgang M.,et al."Evidence for model-based encoding of Pavlovian contingencies in the human brain".NATURE COMMUNICATIONS 10(2019). |
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