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DOI | 10.1038/ncomms15771 |
Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis | |
Ramakrishna, Chandran1; Kujawski, Maciej1; Chug, Hiutung2; Li, Lin1; Mazmanian, Sarkis K.2; Cantin, Edouard M.1 | |
2019-05-14 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The gut commensal Bacteroides fragilis or its capsular polysaccharide A (PSA) can prevent various peripheral and CNS sterile inflammatory disorders. Fatal herpes simplex encephalitis (HSE) results from immune pathology caused by uncontrolled invasion of the brainstem by inflammatory monocytes and neutrophils. Here we assess the immunomodulatory potential of PSA in HSE by infecting PSA or PBS treated 129S6 mice with HSV1, followed by delayed Acyclovir (ACV) treatment as often occurs in the clinical setting. Only PSA-treated mice survived, with dramatically reduced brainstem inflammation and altered cytokine and chemokine profiles. Importantly, PSA binding by B cells is essential for induction of regulatory CD4(+) and CD8(+) T cells secreting IL-10 to control innate inflammatory responses, consistent with the lack of PSA mediated protection in Rag(-/-), B cell- and IL-10-deficient mice. Our data reveal the translational potential of PSA as an immunomodulatory symbiosis factor to orchestrate robust protective anti-inflammatory responses during viral infections. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000467836900007 |
WOS关键词 | HERPES-SIMPLEX-VIRUS ; ASPARTATE RECEPTOR ENCEPHALITIS ; MICROBIOTA INTERACTIONS ; ANTIVIRAL IMMUNITY ; GUT MICROBIOTA ; COMMENSAL ; AUTOIMMUNE ; DISEASE ; MICE ; DIAGNOSIS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203339 |
专题 | 资源环境科学 |
作者单位 | 1.City Hope Natl Med Ctr, Beckman Res Inst, Dept Mol Immunol, Duarte, CA 91010 USA; 2.CALTECH, Div Biol & Biol Sci, Pasadena, CA 91125 USA |
推荐引用方式 GB/T 7714 | Ramakrishna, Chandran,Kujawski, Maciej,Chug, Hiutung,et al. Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Ramakrishna, Chandran,Kujawski, Maciej,Chug, Hiutung,Li, Lin,Mazmanian, Sarkis K.,&Cantin, Edouard M..(2019).Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.NATURE COMMUNICATIONS,10. |
MLA | Ramakrishna, Chandran,et al."Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis".NATURE COMMUNICATIONS 10(2019). |
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