Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/ncomms15905 |
Numerous cultivated and uncultivated viruses encode ribosomal proteins | |
Mizuno, Carolina M.1; Guyomar, Charlotte2; Roux, Simon3; Lavigne, Regis4; Rodriguez-Valera, Francisco5; Sullivan, Matthew B.6,7; Gillet, Reynald2; Forterre, Patrick1; Krupovic, Mart1 | |
2019-02-14 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | France; USA; Spain |
英文摘要 | Viruses modulate ecosystems by directly altering host metabolisms through auxiliary metabolic genes. However, viral genomes are not known to encode the core components of translation machinery, such as ribosomal proteins (RPs). Here, using reference genomes and global-scale viral metagenomic datasets, we identify 14 different RPs across viral genomes arising from cultivated viral isolates and metagenome-assembled viruses. Viruses tend to encode dynamic RPs, easily exchangeable between ribosomes, suggesting these proteins can replace cellular versions in host ribosomes. Functional assays confirm that the two most common virus-encoded RPs, bS21 and bL12, are incorporated into 70S ribosomes when expressed in Escherichia coli. Ecological distribution of virus-encoded RPs suggests some level of ecosystem adaptations as aquatic viruses and viruses of animal-associated bacteria are enriched for different subsets of RPs. Finally, RP genes are under purifying selection and thus likely retained an important function after being horizontally transferred into virus genomes. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000458609500008 |
WOS关键词 | TRANSFER-RNA SYNTHETASES ; SEQUENCE ; TRANSLATION ; SYSTEM ; GENES ; PHOSPHORYLATION ; PROCHLOROCOCCUS ; FRAMESHIFT ; EXCHANGE ; HOSTS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203359 |
专题 | 资源环境科学 |
作者单位 | 1.Inst Pasteur, Unite Biol Mol Gene Extremophiles, Dept Microbiol, F-75015 Paris, France; 2.Univ Rennes, CNRS, IGDR, UMR 6290, F-35000 Rennes, France; 3.US DOE, Joint Genome Inst, Walnut Creek, CA 94598 USA; 4.Univ Rennes, INSERM, EHESP, Irset,UMR S 1085,PROTIM, F-35000 Rennes, France; 5.Univ Miguel Hernandez, Dept Prod Vegetal & Microbiol, Evolutionary Genom Grp, Alicante 03550, Spain; 6.Ohio State Univ, Dept Microbiol, 484 W 12th Ave, Columbus, OH 43210 USA; 7.Ohio State Univ, Dept Civil Environm & Geodet Engn, Columbus, OH 43210 USA |
推荐引用方式 GB/T 7714 | Mizuno, Carolina M.,Guyomar, Charlotte,Roux, Simon,et al. Numerous cultivated and uncultivated viruses encode ribosomal proteins[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Mizuno, Carolina M..,Guyomar, Charlotte.,Roux, Simon.,Lavigne, Regis.,Rodriguez-Valera, Francisco.,...&Krupovic, Mart.(2019).Numerous cultivated and uncultivated viruses encode ribosomal proteins.NATURE COMMUNICATIONS,10. |
MLA | Mizuno, Carolina M.,et al."Numerous cultivated and uncultivated viruses encode ribosomal proteins".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论