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DOI | 10.1038/s41467-017-00092-8 |
Absorbable hemostatic hydrogels comprising composites of sacrificial templates and honeycomb-like nanofibrous mats of chitosan | |
Leonhardt, Eric E.1,2,3,4; Kang, Nari1,2,3,4; Hamad, Mostafa A.5; Wooley, Karen L.1,2,3,4; Elsabahy, Mahmoud1,2,3,4,6,7,8 | |
2019-05-24 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Egypt |
英文摘要 | The development of hemostatic technologies that suit a diverse range of emergency scenarios is a critical initiative, and there is an increasing interest in the development of absorbable dressings that can be left in the injury site and degrade to reduce the duration of interventional procedures. In the current study, beta-cyclodextrin polyester (CDPE) hydrogels serve as sacrificial macroporous carriers, capable of degradation under physiological conditions. The CDPE template enables the assembly of imprinted chitosan honeycomb-like monolithic mats, containing highly entangled nanofibers with diameters of 9.2 +/- 3.7 nm, thereby achieving an increase in the surface area of chitosan to improve hemostatic efficiency. In vivo, chitosan-loaded cyclodextrin (CDPE-Cs) hydrogels yield significantly lower amounts of blood loss and shorter times to hemostasis compared with commercially available absorbable hemostatic dressings, and are highly biocompatible. The designed hydrogels demonstrate promising hemostatic efficiency, as a physiologically-benign approach to mitigating blood loss in tissue-injury scenarios. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000468857900014 |
WOS关键词 | CHITIN ; HEMORRHAGE ; EXPERIENCE ; DRESSINGS ; EFFICACY ; SPONGES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203367 |
专题 | 资源环境科学 |
作者单位 | 1.Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA; 2.Texas A&M Univ, Dept Chem Engn, College Stn, TX 77842 USA; 3.Texas A&M Univ, Dept Mat Sci & Engn, College Stn, TX 77842 USA; 4.Texas A&M Univ, Lab Synthet Biol Interact, College Stn, TX 77842 USA; 5.Assiut Univ, Fac Med, Dept Surg, Assiut 71515, Egypt; 6.Assiut Univ, Al Rajhy Liver Hosp, Dept Pharmaceut, Assiut 71515, Egypt; 7.Assiut Univ, Al Rajhy Liver Hosp, Assiut Int Ctr Nanomed, Assiut 71515, Egypt; 8.Misr Univ Sci & Technol, 6Th Of October City 12566, Egypt |
推荐引用方式 GB/T 7714 | Leonhardt, Eric E.,Kang, Nari,Hamad, Mostafa A.,et al. Absorbable hemostatic hydrogels comprising composites of sacrificial templates and honeycomb-like nanofibrous mats of chitosan[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Leonhardt, Eric E.,Kang, Nari,Hamad, Mostafa A.,Wooley, Karen L.,&Elsabahy, Mahmoud.(2019).Absorbable hemostatic hydrogels comprising composites of sacrificial templates and honeycomb-like nanofibrous mats of chitosan.NATURE COMMUNICATIONS,10. |
MLA | Leonhardt, Eric E.,et al."Absorbable hemostatic hydrogels comprising composites of sacrificial templates and honeycomb-like nanofibrous mats of chitosan".NATURE COMMUNICATIONS 10(2019). |
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