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DOI | 10.1038/ncomms16008 |
Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster | |
Wilinski, Daniel1; Winzeler, Jasmine1; Duren, William2; Persons, Jenna L.1; Holme, Kristina J.3; Mosquera, Johan2; Khabiri, Morteza4; Kinchen, Jason M.5; Freddolino, Peter L.2,4; Karnovsky, Alla2; Dus, Monica1 | |
2019-09-06 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Metabolites are active controllers of cellular physiology, but their role in complex behaviors is less clear. Here we report metabolic changes that occur during the transition between hunger and satiety in Drosophila melanogaster. To analyze these data in the context of fruit fly metabolic networks, we developed Flyscape, an open-access tool. We show that in response to eating, metabolic profiles change in quick, but distinct ways in the heads and bodies. Consumption of a high sugar diet dulls the metabolic and behavioral differences between the fasted and fed state, and reshapes the way nutrients are utilized upon eating. Specifically, we found that high dietary sugar increases TCA cycle activity, alters neurochemicals, and depletes 1-carbon metabolism and brain health metabolites N-acetyl-aspartate and kynurenine. Together, our work identifies the metabolic transitions that occur during hunger and satiation, and provides a platform to study the role of metabolites and diet in complex behavior. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000484599900002 |
WOS关键词 | BRAIN ENERGY-METABOLISM ; N-ACETYLASPARTATE ; FEEDING-BEHAVIOR ; NUTRIENT SENSOR ; SUGAR ; TASTE ; NEURONS ; VISUALIZATION ; INTEGRATION ; CYTOSCAPE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203370 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Michigan, Dept Mol Cellular & Dev Biol, Coll Literature Sci & Arts, Ann Arbor, MI 48109 USA; 2.Univ Michigan, Sch Med, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA; 3.Univ Michigan, Sch Med, Grad Program Mol & Integrat Physiol, Ann Arbor, MI 48109 USA; 4.Univ Michigan, Sch Med, Dept Biol Chem, Ann Arbor, MI 48109 USA; 5.Metabolon Inc, Morrisville, NC 27560 USA |
推荐引用方式 GB/T 7714 | Wilinski, Daniel,Winzeler, Jasmine,Duren, William,et al. Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Wilinski, Daniel.,Winzeler, Jasmine.,Duren, William.,Persons, Jenna L..,Holme, Kristina J..,...&Dus, Monica.(2019).Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster.NATURE COMMUNICATIONS,10. |
MLA | Wilinski, Daniel,et al."Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster".NATURE COMMUNICATIONS 10(2019). |
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