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DOI | 10.1038/ncomms16010 |
Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line | |
Vorobyev, Artem1; 39;chenko, Stanislav2 | |
2019-09-10 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; Switzerland; USA; Japan |
英文摘要 | Phenotypic variation of quantitative traits is orchestrated by a complex interplay between the environment (e.g. diet) and genetics. However, the impact of gene-environment interactions on phenotypic traits mostly remains elusive. To address this, we feed 1154 mice of an autoimmunity-prone intercross line (AIL) three different diets. We find that diet substantially contributes to the variability of complex traits and unmasks additional genetic susceptibility quantitative trait loci (QTL). By performing whole-genome sequencing of the AIL founder strains, we resolve these QTLs to few or single candidate genes. To address whether diet can also modulate genetic predisposition towards a given trait, we set NZM2410/J mice on similar dietary regimens as AIL mice. Our data suggest that diet modifies genetic susceptibility to lupus and shifts intestinal bacterial and fungal community composition, which precedes clinical disease manifestation. Collectively, our study underlines the importance of including environmental factors in genetic association studies. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000484991700003 |
WOS关键词 | METABOLIC SYNDROME ; POTENTIAL ROLE ; MICE ; RNA ; IDENTIFICATION ; EXPRESSION ; HERITABILITY ; ENVIRONMENT ; PSORIASIS ; SEQUENCES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203379 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Lubeck, Lubeck Inst Expt Dermatol, Ratzeburger Allee 160, D-23562 Lubeck, Germany; 2.Univ Lubeck, Ctr Res Inflammat Skin, Ratzeburger Allee 160, D-23562 Lubeck, Germany; 3.Univ Lubeck, Dept Dermatol, Ratzeburger Allee 160, D-23562 Lubeck, Germany; 4.Univ Lubeck, Inst Nutr Med, Labs Immunol & Antibody Glycan Anal, Ratzeburger Allee 160, D-23562 Lubeck, Germany; 5.Univ Med Ctr Schleswig Holstein, Ratzeburger Allee 160, D-23562 Lubeck, Germany; 6.Max Planck Inst Evolutionary Biol, August Thienemann Str 2, D-24306 Plon, Germany; 7.Univ Kiel, Inst Expt Med, Christian Albrechts Pl 4, D-24118 Kiel, Germany; 8.Univ Lubeck, Inst Nutr Med, Mol Gastroenterol, Ratzeburger Allee 160, D-23562 Lubeck, Germany; 9.Univ Lubeck, Inst Syst Inflammat Res, Ratzeburger Allee 160, D-23562 Lubeck, Germany; 10.Goethe Univ, Dept Dermatol Venereol & Allergol, Theodor Stern Kai 7, D-60590 Frankfurt, Germany; 11.Univ Geneva, Geneva Univ Hosp, Div Dermatol & Venereol, Rue Gabrielle Perret Gentil 4, CH-1205 Geneva, Switzerland; 12.Univ Geneva, Dept Pathol & Immunol, Rue Gabrielle Perret Gentil 4, CH-1205 Geneva, Switzerland; 13.Brigham & Womens Hosp, Dept Pathol, Ctr Excellence Vasc Biol, 75 Francis St, Boston, MA 02115 USA; 14.Harvard Med Sch, 75 Francis St, Boston, MA 02115 USA; 15.Univ Rostock, Inst Biostat & Informat Med & Ageing Res, Ernst Heydemann Str 8, D-18057 Rostock, Germany; 16.Kurume Univ, Sch Med, Dept Dermatol, 67 Asahimachi, Kurume, Fukuoka 8300011, Japan; 17.Univ Med Ctr Goettingen, Dept Urol, Robert Koch Str 40, D-37075 Gottingen, Germany; 18.Univ Tokyo, Dept Nephrol & Endocrinol, 7 Chome 3-1 Hongo, Bunkyo City, Tokyo 1138654, Japan |
推荐引用方式 GB/T 7714 | Vorobyev, Artem,39;chenko, Stanislav. Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Vorobyev, Artem,&39;chenko, Stanislav.(2019).Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line.NATURE COMMUNICATIONS,10. |
MLA | Vorobyev, Artem,et al."Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line".NATURE COMMUNICATIONS 10(2019). |
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