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DOI | 10.1038/s41467-017-00119-0 |
Site-specific cleavage of bacterial MucD by secreted proteases mediates antibacterial resistance in Arabidopsis | |
Wang, Yiming1; Garrido-Oter, Ruben1,2; Wu, Jingni1,4; Winkelmueller, Thomas M.1; Agler, Matthew1,5; Colby, Thomas3,6; Nobori, Tatsuya1; Kemen, Eric1,7; Tsuda, Kenichi1 | |
2019-06-28 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; Peoples R China |
英文摘要 | Plant innate immunity restricts growth of bacterial pathogens that threaten global food security. However, the mechanisms by which plant immunity suppresses bacterial growth remain enigmatic. Here we show that Arabidopsis thaliana secreted aspartic protease 1 and 2 (SAP1 and SAP2) cleave the evolutionarily conserved bacterial protein MucD to redundantly inhibit the growth of the bacterial pathogen Pseudomonas syringae. Antibacterial activity of SAP1 requires its protease activity in planta and in vitro. Plants overexpressing SAP1 exhibit enhanced MucD cleavage and resistance but incur no penalties in growth and reproduction, while sap1 sap2 double mutant plants exhibit compromised MucD cleavage and resistance against P. syringae. P. syringae lacking mucD shows compromised growth in planta and in vitro. Notably, growth of Delta mucD complemented with the non-cleavable MucD(F106Y) is not affected by SAP activity in planta and in vitro. Our findings identify the genetic factors and biochemical process underlying an antibacterial mechanism in plants. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000473132200017 |
WOS关键词 | SYRINGAE PV. TOMATO ; PSEUDOMONAS-AERUGINOSA ; GENOME SEQUENCE ; ANTIMICROBIAL PEPTIDES ; PLANTS ; DEFENSE ; IDENTIFICATION ; GROWTH ; INFORMATION ; TRANSFERRIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203389 |
专题 | 资源环境科学 |
作者单位 | 1.Max Planck Inst Plant Breeding Res, Dept Plant Microbe Interact, Carl von Linne Weg 10, D-50829 Cologne, Germany; 2.Heinrich Heine Univ Dusseldorf, Cluster Excellence Plant Sci, D-40225 Dusseldorf, Germany; 3.Max Planck Inst Plant Breeding Res, Plant Prote Grp, Carl von Linne Weg 10, D-50829 Cologne, Germany; 4.Chinese Acad Sci, Inst Plant Physiol & Ecol, Shanghai 200032, Peoples R China; 5.Friedrich Schiller Univ Jena, Inst Microbiol, Plant Microbiosis Lab, Neugasse 23, D-07743 Jena, Germany; 6.Max Planck Inst Biol Ageing, Joseph Stelzmann Str 9B, D-50931 Cologne, Germany; 7.Univ Tubingen, Interfac Inst Microbiol & Infect Med Tubingen, Ctr Plant Mol Biol, Morgenstelle 32, D-72076 Tubingen, Germany |
推荐引用方式 GB/T 7714 | Wang, Yiming,Garrido-Oter, Ruben,Wu, Jingni,et al. Site-specific cleavage of bacterial MucD by secreted proteases mediates antibacterial resistance in Arabidopsis[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Wang, Yiming.,Garrido-Oter, Ruben.,Wu, Jingni.,Winkelmueller, Thomas M..,Agler, Matthew.,...&Tsuda, Kenichi.(2019).Site-specific cleavage of bacterial MucD by secreted proteases mediates antibacterial resistance in Arabidopsis.NATURE COMMUNICATIONS,10. |
MLA | Wang, Yiming,et al."Site-specific cleavage of bacterial MucD by secreted proteases mediates antibacterial resistance in Arabidopsis".NATURE COMMUNICATIONS 10(2019). |
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