Intestinal non-canonical NF kappa B signaling shapes the local and systemic immune response

doi:10.1038/s41467-017-00222-2

GSTDTAP > 资源环境科学

DOI	10.1038/s41467-017-00222-2
	Intestinal non-canonical NF kappa B signaling shapes the local and systemic immune response
	Ramakrishnan, Sadeesh K.1; Zhang, Huabing 2; Ma, Xiaoya 2; Jung, Inkyung 2; Schwartz, Andrew J.2; Triner, Daniel 2; Devenport, Samantha N.2; Das, Nupur K.2; Xue, Xiang 2; Zeng, Melody Y.3,4; Hu, Yinling 5; Mortensen, Richard M.2; Greenson, Joel K.3; Cascalho, Marilia 6,7,8; Wobus, Christiane E.; Colacino, Justin A.9,10; Nunez, Gabriel 3,11; Rui, Liangyou 2,4; Shah, Yatrik M.2,4
	2019-02-08
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
出版年	2019
卷号	10
文章类型	Article
语种	英语
国家	USA
英文摘要	Microfold cells (M-cells) are specialized cells of the intestine that sample luminal microbiota and dietary antigens to educate the immune cells of the intestinal lymphoid follicles. The function of M-cells in systemic inflammatory responses are still unclear. Here we show that epithelial non-canonical NFkB signaling mediated by NFkB-inducing kinase (NIK) is highly active in intestinal lymphoid follicles, and is required for M-cell maintenance. Intestinal NIK signaling modulates M-cell differentiation and elicits both local and systemic IL-17A and IgA production. Importantly, intestinal NIK signaling is active in mouse models of colitis and patients with inflammatory bowel diseases; meanwhile, constitutive NIK signaling increases the susceptibility to inflammatory injury by inducing ectopic M-cell differentiation and a chronic increase of IL-17A. Our work thus defines an important function of non-canonical NFkB and M-cells in immune homeostasis, inflammation and polymicrobial sepsis.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000458175300009
WOS关键词	COLONIC M CELLS ; IKK-ALPHA ; STAT3 ACTIVATION ; GUT MICROBIOTA ; COLITIS ; MICE ; KINASE ; INFLAMMATION ; SURVIVAL ; INTERLEUKIN-17
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/203407
专题	资源环境科学
作者单位	1.Univ Pittsburgh, Dept Med, 930 Scaife Hall, Pittsburgh, PA 15261 USA; 2.Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA; 3.Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA; 4.Univ Michigan, Internal Med, Ann Arbor, MI 48109 USA; 5.NCI, Canc & Inflammat Program, Ctr Canc Res, NIH, Ft Detrick, MD 21702 USA; 6.Univ Michigan, Transplantat Biol, Ann Arbor, MI 48109 USA; 7.Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA; 8.Univ Michigan, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA; 9.Univ Michigan, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA; 10.Univ Michigan, Dept Nutr Sci, Ann Arbor, MI 48109 USA; 11.Univ Michigan, Comprehens Canc Ctr, Ann Arbor, MI 48109 USA
推荐引用方式 GB/T 7714	Ramakrishnan, Sadeesh K.,Zhang, Huabing,Ma, Xiaoya,et al. Intestinal non-canonical NF kappa B signaling shapes the local and systemic immune response[J]. NATURE COMMUNICATIONS,2019,10.
APA	Ramakrishnan, Sadeesh K..,Zhang, Huabing.,Ma, Xiaoya.,Jung, Inkyung.,Schwartz, Andrew J..,...&Shah, Yatrik M..(2019).Intestinal non-canonical NF kappa B signaling shapes the local and systemic immune response.NATURE COMMUNICATIONS,10.
MLA	Ramakrishnan, Sadeesh K.,et al."Intestinal non-canonical NF kappa B signaling shapes the local and systemic immune response".NATURE COMMUNICATIONS 10(2019).