Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-017-00903-y |
Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy | |
Zhang, Wenjia1,2,3; Hu, Xianglong1,2,3; Shen, Qi1,2,3; Xing, Da1,2,3 | |
2019-04-12 | |
发表期刊 | NATURE COMMUNICATIONS
![]() |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | Cancer cells exhibit slightly elevated levels of reactive oxygen species (ROS) compared with normal cells, and approximately 90% of intracellular ROS is produced in mitochondria. In situ mitochondrial ROS amplification is a promising strategy to enhance cancer therapy. Here we report cancer cell and mitochondria dual-targeting polyprodrug nanoreactors (DT-PNs) covalently tethered with a high content of repeating camptothecin (CPT) units, which release initial free CPT in the presence of endogenous mitochondrial ROS (mtROS). The in situ released CPT acts as a cellular respiration inhibitor, inducing mtROS upregulation, thus achieving subsequent self-circulation of CPT release and mtROS burst. This mtROS amplification endows long-term high oxidative stress to induce cancer cell apoptosis. This current strategy of endogenously activated mtROS amplification for enhanced chemodynamic therapy overcomes the short lifespan and action range of ROS, avoids the penetration limitation of exogenous light in photodynamic therapy, and is promising for theranostics. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000464338100015 |
WOS关键词 | PROGRAMMED CELL-DEATH ; PHOTODYNAMIC THERAPY ; CANCER-THERAPY ; ROS STRESS ; APOPTOSIS ; DELIVERY ; INTERNALIZATION ; DYSFUNCTION ; AMPHIPHILES ; IRRADIATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203458 |
专题 | 资源环境科学 |
作者单位 | 1.South China Normal Univ, MOE Key Lab Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China; 2.South China Normal Univ, Inst Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China; 3.South China Normal Univ, Coll Biophoton, Guangzhou 510631, Guangdong, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Wenjia,Hu, Xianglong,Shen, Qi,et al. Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Zhang, Wenjia,Hu, Xianglong,Shen, Qi,&Xing, Da.(2019).Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy.NATURE COMMUNICATIONS,10. |
MLA | Zhang, Wenjia,et al."Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论