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DOI | 10.1038/s41467-017-01040-2 |
An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis | |
Bhandari, Deepak D.1; Lapin, Dmitry1; Kracher, Barbara1; von Born, Patrick1; Bautor, Jaqueline1; Niefind, Karsten2; Parker, Jane E.1 | |
2019-02-15 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany |
英文摘要 | Plant intracellular NLR receptors recognise pathogen interference to trigger immunity but how NLRs signal is not known. Enhanced disease susceptibility1 (EDS1) heterodimers are recruited by Toll-interleukin1-receptor domain NLRs (TNLs) to transcriptionally mobilise resistance pathways. By interrogating the Arabidopsis EDS1 alpha-helical EP-domain we identify positively charged residues lining a cavity that are essential for TNL immunity signalling, beyond heterodimer formation. Mutating a single, conserved surface arginine (R493) disables TNL immunity to an oomycete pathogen and to bacteria producing the virulence factor, coronatine. Plants expressing a weakly active EDS1(R493A) variant have delayed transcriptional reprogramming, with severe consequences for resistance and countering bacterial coronatine repression of early immunity genes. The same EP-domain surface is utilised by a non-TNL receptor RPS2 for bacterial immunity, indicating that the EDS1 EP-domain signals in resistance conferred by different NLR receptor types. These data provide a unique structural insight to early downstream signalling in NLR receptor immunity. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000458754700015 |
WOS关键词 | SALICYLIC-ACID ; PATHOGEN EFFECTORS ; DEFENSE RESPONSES ; STRUCTURAL BASIS ; RECEPTOR RX1 ; CELL-DEATH ; RESISTANCE ; PAD4 ; RECOGNITION ; BACTERIAL |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203460 |
专题 | 资源环境科学 |
作者单位 | 1.Max Planck Inst Plant Breeding Res, Dept Plant Microbe Interact, Carl von Linne Weg 10, D-50829 Cologne, Germany; 2.Univ Cologne, Dept Chem, Inst Biochem, Zuelpicher Str 47, D-50674 Cologne, Germany |
推荐引用方式 GB/T 7714 | Bhandari, Deepak D.,Lapin, Dmitry,Kracher, Barbara,et al. An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Bhandari, Deepak D..,Lapin, Dmitry.,Kracher, Barbara.,von Born, Patrick.,Bautor, Jaqueline.,...&Parker, Jane E..(2019).An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis.NATURE COMMUNICATIONS,10. |
MLA | Bhandari, Deepak D.,et al."An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis".NATURE COMMUNICATIONS 10(2019). |
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