Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates

doi:10.1038/s41467-017-01626-w

GSTDTAP > 资源环境科学

DOI	10.1038/s41467-017-01626-w
	Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates
	Brannan, Jennifer M.1; He, Shihua 2; Howell, Katie A.3; Prugar, Laura I.1; Zhu, Wenjun 2; Hong Vu 3; Shulenin, Sergey 3; Kailasan, Shweta 3; Raina, Henna 3; Wong, Gary 2,4; Rahim, Md Niaz 2,4; Banadyga, Logan 2; Tierney, Kevin 2; Zhao, Xuelian 5; Li, Yuxing 5,6; Holtsberg, Frederick W.3; Dye, John M.1; Qiu, Xiangguo 2,4; Aman, M. Javad 3
	2019-01-10
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
出版年	2019
卷号	10
文章类型	Article
语种	英语
国家	USA; Canada
英文摘要	The 2013-2016 Ebola virus (EBOV) disease epidemic demonstrated the grave consequences of filovirus epidemics in the absence of effective therapeutics. Besides EBOV, two additional ebolaviruses, Sudan (SUDV) and Bundibugyo (BDBV) viruses, as well as multiple variants of Marburg virus (MARV), have also caused high fatality epidemics. Current experimental EBOV monoclonal antibodies (mAbs) are ineffective against SUDV, BDBV, or MARV. Here, we report that a cocktail of two broadly neutralizing ebolavirus mAbs, FVM04 and CA45, protects nonhuman primates (NHPs) against EBOV and SUDV infection when delivered four days post infection. This cocktail when supplemented by the anti-MARV mAb MR191 exhibited 100% efficacy in MARV-infected NHPs. These findings provide a solid foundation for clinical development of broadly protective immunotherapeutics for use in future filovirus epidemics.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000455354800002
WOS关键词	EBOLA-VIRUS ; BROAD PROTECTION ; GLYCOPROTEIN ; ANTIBODIES ; MECHANISM ; BINDING ; ENTRY
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/203518
专题	资源环境科学
作者单位	1.US Army, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA; 2.Publ Hlth Agcy Canada, Natl Microbiol Lab, Special Pathogens Program, 1015 Arlington St, Winnipeg, MB R3E 3R2, Canada; 3.Integrated BioTherapeut Inc, 4 Res Court,Suite 300, Rockville, MD 20850 USA; 4.Univ Manitoba, Dept Med Microbiol, 745 Bannatyne Ave, Winnipeg, MB R3E 0J9, Canada; 5.Univ Maryland, Sch Med, Dept Microbiol & Immunol, 685 West Baltimore St, Baltimore, MD 21201 USA; 6.Univ Maryland, Inst Biosci & Biotechnol Res, 9600 Gudelsky Dr, Rockville, MD 20850 USA
推荐引用方式 GB/T 7714	Brannan, Jennifer M.,He, Shihua,Howell, Katie A.,et al. Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates[J]. NATURE COMMUNICATIONS,2019,10.
APA	Brannan, Jennifer M..,He, Shihua.,Howell, Katie A..,Prugar, Laura I..,Zhu, Wenjun.,...&Aman, M. Javad.(2019).Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates.NATURE COMMUNICATIONS,10.
MLA	Brannan, Jennifer M.,et al."Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates".NATURE COMMUNICATIONS 10(2019).