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DOI | 10.1038/s41467-017-01791-y |
Cross-lineage protection by human antibodies binding the influenza B hemagglutinin | |
Liu, Yi1; Tan, Hyon-Xhi1; Koutsakos, Marios1; Jegaskanda, Sinthujan1; Esterbauer, Robyn1; Tilmanis, Danielle2; Aban, Malet2; Kedzierska, Katherine1; Hurt, Aeron C.1,2; Kent, Stephen J.1,3,4,5,6; Wheatley, Adam K.1 | |
2019-01-18 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Australia |
英文摘要 | Influenza B viruses (IBV) drive a significant proportion of influenza-related hospitalisations yet are understudied compared to influenza A. Current vaccines target the head of the viral hemagglutinin (HA) which undergoes rapid mutation, significantly reducing vaccine effectiveness. Improved vaccines to control IBV are needed. Here we developed novel IBV HA probes to interrogate humoral responses to IBV in humans. A significant proportion of IBV HA-specific B cells recognise both B/Victoria/2/87-like and B/Yamagata/16/88-like lineages in a distinct pattern of cross-reactivity. Monoclonal antibodies (mAbs) were reconstituted from IBV HA-specific B cells, including mAbs providing broad protection in murine models of lethal IBV infection. Protection was mediated by neutralising antibodies targeting the receptor binding domain, or via Fc-mediated functions of non-neutralising antibodies binding alternative epitopes including the IBV HA stem. This work defines antigenic cross-recognition between IBV lineages and provides guidance for the rational design of improved IBV vaccines for broad and durable protection. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000456011300001 |
WOS关键词 | MONOCLONAL-ANTIBODIES ; VACCINE EFFICACY ; STRUCTURAL BASIS ; VIRUS ; ADULTS ; CHILDREN ; ANTIGEN ; CELLS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203519 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic 3000, Australia; 2.Peter Doherty Inst Infect & Immun, World Hlth Org WHO Collaborating Ctr Reference &, Melbourne, Vic 3000, Australia; 3.Monash Univ, Melbourne Sexual Hlth Ctr, Melbourne, Vic 3004, Australia; 4.Monash Univ, Dept Infect Dis, Alfred Hosp, Melbourne, Vic 3004, Australia; 5.Monash Univ, Cent Clin Sch, Melbourne, Vic 3004, Australia; 6.Univ Melbourne, ARC Ctr Excellence Convergent Bionano Sci & Techn, Parkville, Vic 3010, Australia |
推荐引用方式 GB/T 7714 | Liu, Yi,Tan, Hyon-Xhi,Koutsakos, Marios,et al. Cross-lineage protection by human antibodies binding the influenza B hemagglutinin[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Liu, Yi.,Tan, Hyon-Xhi.,Koutsakos, Marios.,Jegaskanda, Sinthujan.,Esterbauer, Robyn.,...&Wheatley, Adam K..(2019).Cross-lineage protection by human antibodies binding the influenza B hemagglutinin.NATURE COMMUNICATIONS,10. |
MLA | Liu, Yi,et al."Cross-lineage protection by human antibodies binding the influenza B hemagglutinin".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
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