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DOI | 10.1038/s41467-017-01550-z |
STING induces early IFN-beta in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus | |
Tegtmeyer, Pia-Katharina1; Spanier, Julia1; Borst, Katharina1,4; Becker, Jennifer1; Riedl, Andre2; Hirche, Christoph1; Ghita, Luca1; Skerra, Jennifer1; Baumann, Kira1; Lienenklaus, Stefan1,5; Doering, Marius1,6; Ruzsics, Zsolt2; Kalinke, Ulrich1,3 | |
2019-06-27 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; France |
英文摘要 | Cytomegalovirus is a DNA-encoded beta-herpesvirus that induces STING-dependent type 1 interferon responses in macrophages and uses myeloid cells as a vehicle for dissemination. Here we report that STING knockout mice are as resistant to murine cytomegalovirus (MCMV) infection as wild-type controls, whereas mice with a combined Toll-like receptor/RIG-I-like receptor/STING signaling deficiency do not mount type 1 interferon responses and succumb to the infection. Although STING alone is dispensable for survival, early IFN-beta induction in Kupffer cells is STING-dependent and controls early hepatic virus propagation. Infection experiments with an inducible reporter MCMV show that STING constrains MCMV replication in myeloid cells and limits viral dissemination via these cells. By contrast, restriction of viral dissemination from hepatocytes to other organs is independent of STING. Thus, during MCMV infection STING is involved in early IFN-beta induction in Kupffer cells and the restriction of viral dissemination via myeloid cells, whereas it is dispensable for survival. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000473002900003 |
WOS关键词 | NATURAL-KILLER-CELLS ; CYCLIC GMP-AMP ; DENDRITIC CELLS ; IMMUNE-RESPONSES ; INFECTION ; MACROPHAGES ; MONOCYTES ; CGAS ; SPECIALIZATION ; 2ND-MESSENGER |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203585 |
专题 | 资源环境科学 |
作者单位 | 1.Hanover Med Sch & Helmholtz Ctr Infect Res, Inst Expt Infect Res, TWINCORE Ctr Expt & Clin Infect Res, D-30625 Hannover, Germany; 2.Univ Freiburg, Fac Med, Med Ctr, Inst Virol, D-79106 Freiburg, Germany; 3.Hannover Med Sch, Cluster Excellence Resolving Infect Susceptibil, D-30625 Hannover, Germany; 4.Univ Freiburg, Fac Med, Inst Neuropathol, D-79106 Freiburg, Germany; 5.Hannover Med Sch, Imaging Ctr, Cent Anim Facil, D-30625 Hannover, Germany; 6.PSL Res Univ, Immun & Canc Dept, Inst Curie, INSERM U932, F-75005 Paris, France |
推荐引用方式 GB/T 7714 | Tegtmeyer, Pia-Katharina,Spanier, Julia,Borst, Katharina,et al. STING induces early IFN-beta in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Tegtmeyer, Pia-Katharina.,Spanier, Julia.,Borst, Katharina.,Becker, Jennifer.,Riedl, Andre.,...&Kalinke, Ulrich.(2019).STING induces early IFN-beta in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus.NATURE COMMUNICATIONS,10. |
MLA | Tegtmeyer, Pia-Katharina,et al."STING induces early IFN-beta in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus".NATURE COMMUNICATIONS 10(2019). |
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