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DOI | 10.1038/s41467-017-02788-3 |
Microfluidics with fluid walls | |
Walsh, Edmond J.1; Feuerborn, Alexander2; Wheeler, James H. R.3; Tan, Ann Na2; Durham, William M.3,4; Foster, Kevin R.3; Cook, Peter R.2 | |
2017-10-10 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | England |
英文摘要 | Microfluidics has great potential, but the complexity of fabricating and operating devices has limited its use. Here we describe a method - Freestyle Fluidics - that overcomes many key limitations. In this method, liquids are confined by fluid (not solid) walls. Aqueous circuits with any 2D shape are printed in seconds on plastic or glass Petri dishes; then, interfacial forces pin liquids to substrates, and overlaying an immiscible liquid prevents evaporation. Confining fluid walls are pliant and resilient; they self-heal when liquids are pipetted through them. We drive flow through a wide range of circuits passively by manipulating surface tension and hydrostatic pressure, and actively using external pumps. Finally, we validate the technology with two challenging applications - triggering an inflammatory response in human cells and chemotaxis in bacterial biofilms. This approach provides a powerful and versatile alternative to traditional microfluidics. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000412603600001 |
WOS关键词 | DYNAMIC INTERFACIAL-TENSION ; BACTERIAL BIOFILMS ; SURFACE-TENSION ; IMAGE-ANALYSIS ; IV PILI ; DEVICES ; CELLS ; FLOW ; MICROCHANNELS ; ENVIRONMENTS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203642 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Oxford, Dept Engn Sci, Osney Thermo Fluids Lab, Oxford OX2 0ES, England; 2.Univ Oxford, Sir William Dunn Sch Pathol, South Parks Rd, Oxford OX1 3RE, England; 3.Univ Oxford, Dept Zool, South Parks Rd, Oxford OX1 3PS, England; 4.Univ Sheffield, Dept Phys & Astron, Hounsfield Rd, Sheffield S3 7RH, S Yorkshire, England |
推荐引用方式 GB/T 7714 | Walsh, Edmond J.,Feuerborn, Alexander,Wheeler, James H. R.,et al. Microfluidics with fluid walls[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Walsh, Edmond J..,Feuerborn, Alexander.,Wheeler, James H. R..,Tan, Ann Na.,Durham, William M..,...&Cook, Peter R..(2017).Microfluidics with fluid walls.NATURE COMMUNICATIONS,8. |
MLA | Walsh, Edmond J.,et al."Microfluidics with fluid walls".NATURE COMMUNICATIONS 8(2017). |
条目包含的文件 | 条目无相关文件。 |
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